Clinical Trials Logo
  1. Home
  2. Intracranial Atherosclerosis
  3. NCT02534545

Remote Ischemic Conditioning for Avoiding Recurrence of Symptomatic Intracranial Atherosclerotic Stenosis (sICAS)

Intracranial Atherosclerosis Clinical Trial

Official title:
Remote Ischemic Conditioning for Avoiding Recurrence of Ischemic Stroke in Patients With Symptomatic Intracranial Atherosclerotic Stenosis

Clinical Trial Summary

The primary objective of the study will be to determine whether remote limb ischemic conditioning (RLIC) compared with sham RLIC (placebo) treatment reduces the 12-month risk of recurrent IS in patients with a recent TIA or IS caused by stenosis of a major intracranial artery.

After screening period, eligible patients will be randomly allocated into 2 groups. In addition, all participants receive an usual clinical therapy.

Clinical Trial Description

In this study, Patients in the RLIC group will be treated with Renqiao Remote Ischemic Conditioning Device (Doctormate®) (200mmHg) once daily for 12 months; patients in the sham RLIC group will be treated with the Renqiao Remote Ischemic Conditioning Device (Doctormate®) (60mmHg) once daily for 12 months. In the study, the RLIC treatment will be comprised of 5 cycles of bilateral upper limb ischemia and reperfusion, which will be induced by 2 cuffs placed around the upper arms respectively and inflated to 200mmHg for 5 minutes followed by 5 minutes of reperfusion by cuff deflation. Sham RLIC treatment will be conducted using the same procedure but with a minimal inflation pressure of 60mmHg, which does not result in upper limb ischemia. In addition, all participants will have received their usual drug therapy according to local medical practice. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02534545
Study type Interventional
Source Capital Medical University
Contact Xunming Ji, MD. PhD
Phone +86-10-83198952
Email jixunming@vip.163.com
Status Recruiting
Phase N/A
Start date October 2015
Completion date September 2019
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06058130 - Combination of Antiplatelet and Anticoagulation for AIS Patients Witn Concomitant NVAF and Extracranial/Intracranial Artery Stenosis N/A
Completed NCT01838356 - Intracranial Atherosclerosis and Depression After Coronary Artery Bypass Graft N/A
Recruiting NCT05947994 - Credo Stent in the Symptomatic Intracranial Stenosis N/A
Terminated NCT03507374 - PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis Early Phase 1
Recruiting NCT04010955 - Adding Antiplatelet During Edoxaban Treatment in Stroke Patients With Non-valvular Atrial Fibrillation (ADD-ON)
Not yet recruiting NCT05593224 - The Efficacy and Safety of Intracranial Stent (Tonbridge) in Endovascular Treatment of Intracranial Atherosclerotic Stenosis N/A
Recruiting NCT02719652 - Vessel Wall and Perfusion Imaging in Intracranial Atherosclerosis N/A
Active, not recruiting NCT04949880 - A Single-Arm Trial of Neurovascular Drug-Eluting Balloon Dilatation Catheter Treating Symptomatic Intracranial Atherosclerotic Stenosis N/A
Recruiting NCT06336174 - Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Artery Stenosis Patients: A Cohort Study
Recruiting NCT04627870 - ACOART Intracranial ISR Pilot:Intracranial DCB in the Treatment of Intracranial In-stent Restenosis N/A
Recruiting NCT05316311 - A Study of Implantation of CRENEOUS ENTERPRISE 2 Intracranial Stent in Participants With Severe Symptomatic Intracranial Atherosclerotic Stenosis N/A
Not yet recruiting NCT05757505 - The Efficacy and Safety of Intracranial Stent (Tonbridge) in Endovascular Treatment of Symptomatic Intracranial Atherosclerotic Stenosis N/A
Completed NCT02072876 - Asymptomatic Intracranial Atherosclerotic Disease in Pakistanis N/A
Completed NCT01819597 - Surgical Indirect Revascularization For Symptomatic Intracranial Arterial Stenosis N/A
Not yet recruiting NCT06331494 - Efficacy of Butylphthalide on Symptomatic Atherosclerotic Stenosis in Middle Cerebral Artery N/A
Recruiting NCT05550077 - Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis
Completed NCT05203887 - Short- and Long-term Outcomes of Stenting for Symptomatic Intracranial Arterial Stenosis: a Cohort Study
Completed NCT04631055 - ACOART Intracranial de Novo:DCB in the Treatment of Symptomatic Intracranial Atherosclerotic de Novo Stenosis N/A
Completed NCT05631470 - Diagnostic Accuracy for Hemodynamically ICAS of MR-FFR Comparing With Pressure-wire-based FFR.
Completed NCT03208166 - Pilot Study of Pre-Ischemic Conditioning for Intracranial Atherosclerosis N/A