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Intracranial Arterial Stenosis clinical trials

View clinical trials related to Intracranial Arterial Stenosis.

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NCT ID: NCT02041117 Completed - Clinical trials for Intracranial Arterial Stenosis

Resuvastatin Treatment for Symptomatic Middle Cerebral Artery Stenosis Based on High-resolution Magnetic Resonance Imaging

REALM
Start date: February 24, 2014
Phase: Phase 4
Study type: Interventional

1. It is a multicenter, open-label, sing arm study to evaluate the effects of treatment of Rosuvastatin 10-20mg in volume and morphology of atherosclerotic plague by reducing LDL-C level to or less than 70mg/dl. 2. Ischemic stroke patients will be enrolled within 1 month after stroke onset. 3. Patients will be visited at 0m, 1m, 3m, 6m, 9m, 12m, 18m and 24m.

NCT ID: NCT01819597 Completed - Ischemic Stroke Clinical Trials

Surgical Indirect Revascularization For Symptomatic Intracranial Arterial Stenosis

ERSIAS
Start date: March 2013
Phase: N/A
Study type: Interventional

Stroke due to intracranial arterial atherosclerosis is a significant medical problem, carrying one of the highest rates of recurrent stroke despite best medical therapy, with annual recurrence rates as elevated as 25% in high risk groups. The goal of this investigation is to advance a promising surgical treatment for symptomatic atherosclerotic intracranial stenosis - encephaloduroarteriosynangiosis (EDAS). The investigation will test in a phase II futility trial the potential of EDAS for further development before proceeding with the design of a definitive clinical trial of EDAS Revascularization in patients with Symptomatic Intracranial Arterial Stenosis (ERSIAS). The investigation is a 4-year futility trial to test the hypothesis that EDAS revascularization combined with aggressive medical therapy warrants further evaluation in a subsequent pivotal trial as an alternative to aggressive medical management alone for preventing the primary endpoint of stroke or death in patients with symptomatic intracranial arterial stenosis (Specific Aim 1). During the investigation the time course of collateralogenesis and perfusion improvement following EDAS will also be evaluated (Specific Aim 2.

NCT ID: NCT01570231 Completed - Clinical trials for Intracranial Arterial Stenosis

Feasibility, Safety and Efficacy of Remote Ischemic Preconditioning for Symptomatic Intracranial Arterial Stenosis in Octogenarians

Start date: January 2008
Phase: Phase 1
Study type: Interventional

Making a limb transiently ischemic induces ischemic tolerance in distant organs such as the heart. This study aims to evaluate the feasibility, safety and initial efficacy of using briefly repetitive bilateral limb ischemic preconditioning (BLIPC) to protect the brain in octogenarians with symptomatic intracranial arterial stenosis.