Establishment of Online Registration Platform for Unruptured Intracranial

Status Recruiting

Clinical Trial Summary

Intracranial aneurysm is the main cause of subarachnoid hemorrhage, and the incidence of subarachnoid hemorrhage in Chinese population is about 5%. The intervention of unruptured intracranial aneurysms is controversial because of its great harm after natural rupture and bleeding, and about a quarter of patients still have poor prognosis through existing invasive treatment methods. How to accurately determine the instability risk of unruptured intracranial aneurysms is the key to resolve this controversy. In previous studies, the stability of intracranial aneurysms involves many characteristics, and the sample size is small. Most of them are retrospective studies and studies on the status after change (rupture/growth). Therefore, the relevant risk factors are not clear at present, and there is still a lack of reliable prediction model. Based on the above facts, this study proposed based on the national hundred regional medical institutions set up the network registration platform of unruptured intracranial aneurysms, real time and openness of Internet, through the way of case resource sharing build unruptured intracranial aneurysm queue, collecting clinical characteristics, imaging features, hemodynamic detection of biological samples and the results of the analysis data, And observe them for two years. The artificial intelligence platform of Tonglian Medical Health was used to integrate and analyze and learn all the data, and then the risk factors related to the stability of intracranial aneurysms within two years were obtained, and the stability prediction model of unruptured intracranial aneurysms was constructed. This study will build the largest network registration platform and population follow-up cohort of unruptured intracranial aneurysms in China, and put forward a prediction model for the stability of unruptured intracranial aneurysms by integrating the multi-dimensional factors of intracranial aneurysms, so as to provide a powerful auxiliary judgment tool for the clinical decision-making of this disease.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05608122
Study type	Observational [Patient Registry]
Source	Beijing Tiantan Hospital
Contact
Status	Recruiting
Phase
Start date	October 30, 2022
Completion date	October 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04870047` - Coating to Optimize Aneurysm Treatment In The New Flow Diverter Generation	N/A
Recruiting	`NCT05968053` - Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)
Not yet recruiting	`NCT05665309` - Interest of Pre-operative Use of 3D Printing for Endovascular Treatment of Unruptured Intracranial Aneurysms With Intrasaccular Flow Disruptor	N/A
Completed	`NCT02783339` - Neuroform Atlas Stent for Intracranial Aneurysm Treatment
Withdrawn	`NCT01194388` - Axium Coil in Completing Endovascular Aneurysm Surgery Study
Completed	`NCT00071565` - Familial Intracranial Aneurysm Study II	N/A
Recruiting	`NCT05409989` - MicroVention, Inc. Flow Re-Direction Endoluminal Device X (FRED™ X™) Post-Approval Study	N/A
Completed	`NCT03680742` - Contour Neurovascular System - European Pre-Market Unruptured Aneurysm	N/A
Completed	`NCT04872842` - Establishment of Online Registration Platform for Unruptured Intracranial Aneurysms Based on 100 Regional Medical Centers in China and Population Follow-up Study
Terminated	`NCT02532517` - Study to Evaluate the Safety and Effectiveness of the CODMAN ENTERPRISE® Vascular Reconstruction Device	N/A
Completed	`NCT03663257` - Study to Evaluate Cerebral AneurysmFlow Results in Occlusion
Recruiting	`NCT06189950` - Registration Trial of the Intracranial Visualized Stent for the Wide-necked Intracranial Aneurysms:REBRIDGE	N/A
Recruiting	`NCT03661463` - Unruptured Intracranial Aneurysm Aspirin Trial (UIAAT).	Phase 2
Completed	`NCT02609867` - A Feasibility Study to Evaluate the Safety and Effectiveness of Implantation of Flowise Cerebral Flow Diverter (Flowise)	N/A
Active, not recruiting	`NCT02292017` - Prospective Packing Density With Target Coils I	N/A
Active, not recruiting	`NCT01872741` - Minipterional Versus Pterional Craniotomy	N/A
Completed	`NCT00993057` - Efficiency of Two Glucose Sampling Protocols for Maintenance of Euglycemia	Early Phase 1
Completed	`NCT00777088` - Pipeline for Uncoilable or Failed Aneurysms	N/A
Completed	`NCT00777907` - Complete Occlusion of Coilable Aneurysms	Phase 3
Not yet recruiting	`NCT05060185` - The Flow Diverter for Treating Patients With Intracranial Aneurysms	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Establishment of Online Registration Platform for Unruptured Intracranial Aneurysms Based on Regional Medical Centers in China and Population Follow-up Study (Phase Ⅱ)

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms