Interstitial Lung Disease, Desquamative Clinical Trial
Official title:
Sequential Changes of Serum KL-6 Predict Progression in Interstitial Lung Disease
Interstitial lung disease is a chronic progressive fibrosis lung disease that with a highly variable clinical process.thence it is significant for the patient to search a convenient and accurate prediction method. The objective of this study was to determine whether peripheral blood biomarkers can predict disease .
The median follow-up period was 12 months, each patient received 4 or 5 follow-ups in our
center, 336 person-times in study enrollment totally. The patients with interstitial lung
disease had significantly higher serum baseline KL-6 and MMP-7 levels compared with healthy
control.They divided into progressive group and non-progressive group according to disease
change. Serum KL-6 and MMP-7 levels were elevated in patients if disease progression, but
baseline level of biomarkers in progressive group were not significant higher compare with
non-progressive group .Binary logistic regression showed △KL-6 and △MMP-7 were significant
predictors for disease progression. Multivariate Cox analysis showed KL-6 and MMP-7 were
significantly associated with survival along with other variables.
The serum levels of KL-6 and MMP-7 were elevated in the individuals with interstitial lung
disease compared with healthy controls. The rate of poor prognosis and mortality more
associated with the variability increased biomarker concentrations，rather than the baseline
concentration.Therefore，Serial measurements of biomarkers contribute to the disease
monitoring in clinical management.
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Observational Model: Cohort, Time Perspective: Prospective