Identifying Genetic Causes of IC/BPS

Interstitial Cystitis Clinical Trial

Official title: Genetic Studies in Interstitial Cystitis/Bladder Pain Syndrome/Chronic Pelvic Pain Syndrome (IC/BPS/CPPS)

Status Recruiting

Clinical Trial Summary

Interstitial cystitis (IC), also called Bladder Pain syndrome (BPS), or chronic pelvic pain syndrome(CPPS) is a common condition with no known cause or cure. Twin studies and family accounts have suggested that the condition may be genetic or passed down (inherited) from one generation to another.

In this study, we are collecting genetic material and medical information from families in North America in an attempt to identify genetic factors that may cause IC/BPS/CPPS. We are enrolling families and individuals with IC/BPS/CPPS and their family members (both family members with and without IC like symptoms).

Clinical Trial Description

We are trying to identify a genetic cause of interstitial cystitis (IC)/bladder pain syndrome (BPS)/chronic pelvic pain syndrome (CPPS). We will enroll individuals and families with IC/BPS/CPPS to fully describe the symptoms of IC/PBS/CPPS in adults and children. We will attempt to determine if the symptoms of IC/PBS/CPPS match or indicate changes in specific genes or a pathway of connected genes. We will use several genetic technologies including but not limited to; linkage analysis, whole exome sequencing and candidate gene studies to try to identify the cause of IC/BPS/CPPS. We hope this will lead us to better more effective treatments for affected individuals. We are looking for families with IC/BPS/CPPS symptoms to give a DNA sample (from blood/saliva), urine samples, bladder tissue from clinical biopsy and answer several questionnaires. Travel to Boston NOT necessary. ;

Related Conditions & MeSH terms

• Bladder Pain Syndrome
• Chronic Pelvic Pain Syndrome
• Cystitis
• Cystitis, Interstitial
• Interstitial Cystitis
• Pelvic Pain
• Somatoform Disorders
• Syndrome

• NCT number: NCT00389142
• Study type: Observational
• Source: Boston Children's Hospital
• Contact: Elicia A Estrella, MS, LCGC
• Phone: 617-919-4552
• Email: elicia.estrella@childrens.harvard.edu
• Status: Recruiting
• Start date: January 15, 2006
• Completion date: December 31, 2026