Intellectual Disability Clinical Trial
Official title:
Clinical Collaborative Research of Whole Genome Sequencing in the Detection of Rare Undiagnosed Genetic Diseases in Children in China
To assess the indications and diagnostic efficiency of whole genome sequencing (WGS) in pediatric patients with unexplained intellectual disability/developmental delay, multiple congenital abnormalities and other rare and undiagnosed diseases
This project will recruit 100 rare, undiagnosed pediatric genetic disease families (core
families: patients, patients' parents, immediate family members such as brothers and sisters,
all of them can be enrolled whether they have disease or not, so generally 3, for a few cases
4 or 5) all over the country. The expert team will review the clinical materials, the
molecular team will review the experimental process, and the bioinformatics team will review
the chip, the analysis of whole exome sequencing data and screen the samples all over the
country;
Whole-genome sequencing of 100 rare, undiagnosed pediatric genetic disease families (Illumina
NovaSeq High-throughput Sequencer);
The study will provide preliminarily performance data on the comparison of whole exome data
and whole genome data. In addition, it will generate the Chinese Consensus on Clinical
Applications of Whole-genome sequencing in the Diagnosis of Birth Defects and Undiagnosed
Rare Genetic Diseases in Children based on the statistical analysis of clinical phenotype and
genotype association, which could guide the clinical application of pediatrics, laboratory
testing and reporting.
Construction of the Chinese detection genome database of genetic disease
;
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