Wound Healing Clinical Trial
Official title:
Effects of Local Insulin on Wound Angiogenesis and Fibroplasia in Varicose Ulcers
A randomized, split-plot, double-blind, placebo-controlled trial. The varicose ulcer is divided into two (side A and B). Half of the wound's surface is treated locally with insulin (Glargine) applied at an approx depth of 3-4 mm. Treatment with insulin is administered for 7 days. Biopsy specimens of the two sides are obtained on days 0 and 7. A thermographic photograph of the wound is taken at days 0 and 7. The number of blood vessels and fibroplasia is evaluated as the main outcome.
A randomized, split-plot, double-blind, placebo-controlled trial. Chronic Varicose Ulcers
measuring more than 4 cm in any of its dimensions, and that comply with candidate criteria
are included in the present study. A split-mouth model is used.
The ulcer is divided into two (sides A and B). The side in which treatment is applied is
randomized. Half of the wound's surface is treated locally with insulin (Glargine) applied at
an approx depth of 3-4 mm. Both halves are covered with dressings and compression therapy is
applied. Treatment with insulin is administered for 7 days. Biopsy specimens of the two sides
are obtained on days 0 and 7. A thermographic photograph of the wound is taken at days 0 and
7, as control of the local temperature of the wound. This is to asses the process of healing
and to correlate with our outcome measures. The number of blood vessels will be evaluated as
the main outcome. Fibroplasia and thermal asymmetry between wound sides will be evaluated as
secondary outcomes.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05045183 -
A Study to Assess Wound Healing Efficacies of Different Clean, Treat, and Protect Wound Care Regimens Compared to Standard of Care and Untreated
|
N/A | |
| Enrolling by invitation |
NCT04613336 -
Efficacy of Topical Heparin Spray on Donor Site Wound Healing Time Compared to Conventional Dressing Among Patients Undergoing Split Thickness Skin Grafting
|
||
| Recruiting |
NCT02241811 -
Wound Treatment With 3% Sodium Pentaborate Pentahydrate
|
Phase 1 | |
| Completed |
NCT02797899 -
Effect of PRF Palatal Bandage on Pain Scores and Wound Healing After Free Gingival Graft
|
N/A | |
| Completed |
NCT01227759 -
Tyrosur® Gel-Investigation on Wound Healing Efficacy
|
Phase 2 | |
| Completed |
NCT01061502 -
Efficacy Study of a Bioelectric Dressing to Treat Skin Graft Donor Site Wounds
|
Phase 1/Phase 2 | |
| Completed |
NCT00736593 -
A Study Evaluating Nexagon™ in the Treatment of Skin Wounds.
|
Phase 1 | |
| Completed |
NCT00977951 -
Genomic Changes Associated With the Use of Intradermal Avotermin (Juvista) in Small Wounds in Healthy Male Subjects
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT03872544 -
Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
|
||
| Enrolling by invitation |
NCT03880188 -
Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
|
||
| Recruiting |
NCT05191082 -
Manufacturing, Characterization and Evaluation of the Effect of Silk Fibroin Membranes, Loaded or Not With Neurotensins on Open Wounds in the Palate
|
N/A | |
| Enrolling by invitation |
NCT05942235 -
The Use of Microlearning in Nursing Education
|
||
| Completed |
NCT03433820 -
Wound Healing in Healthy Volunteers
|
N/A | |
| Withdrawn |
NCT02383992 -
Postoperative Care of Sutured Wounds
|
N/A | |
| Recruiting |
NCT02034539 -
VADOplex Critical Limb Ischemia Study
|
Phase 2/Phase 3 | |
| Recruiting |
NCT01680042 -
Clinical Effect of Phenytoin Mucoadhesive Paste on Wound Healing After Oral Biopsy
|
Phase 1 | |
| Completed |
NCT01734317 -
An Open Single-centre Investigation Evaluating Efficacy in Second Degree Partial Thickness Burns Using a Silicone Contact Layer Containing Silver.
|
N/A | |
| Completed |
NCT01115218 -
The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy
|
||
| Withdrawn |
NCT01008111 -
Wound Healing of Incisional Wounds for Bilateral Hernia Repair
|
Phase 1 | |
| Completed |
NCT00984503 -
Investigation of the Accelerated Healing and Anti-scarring Potential of Avotermin (Juvista) in Split Skin Graft Donor Sites
|
Phase 2 |