Obesity Clinical Trial
Official title:
Mechanisms Underlying the Improvement of Insulin Resistance in Response to Bariatric Surgery
Non-randomized open label study to investigate factors mediating changes in insulin sensitivity, glucose tolerance and other metabolic outcomes after bariatric surgery.
Bariatric and weight loss surgery is an effective treatment for severe obesity. Bariatric
surgery also decreases insulin resistance and improves diabetes. Our study enrolled
individuals approved for bariatric surgery to collect data on modifiable predictors and
laboratory outcomes. These data would allow us to systematically assess clinical outcomes
over one year post bariatric surgery and elucidate how insulin resistance is decreased and
diabetes is improved.
The type of surgery was selected by the subjects between Roux-en-Y gastric bypass or a
laparoscopic adjustable gastric banding. Participation in the study involved having a small
sample of tissue obtained from the abdomen and subjects were also given the option to have a
biopsy performed in the thigh area during their elective surgical procedure (optional adipose
and muscle tissue biopsies).
Subjects were examined prior to surgery and at 2, 3, 6 months after intervention.
Anthropometric and body composition measurements were performed using the Bioelectrical
Impendence Analysis (BIA) before surgery and 6 months post operatively. Morning blood was
collected after overnight fasting during each visit. Some of the non-diabetic subjects
completed a mixed nutrient stimulation study during the baseline and 6-month visit. Blood
samples were collected immediately prior to drinking the liquid drink, and every 30 minutes
after the meal ingestion for 2 hours.
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