Acute Microbial Switch

Status Not yet recruiting

Clinical Trial Summary

In this project the investigators will test if it is possible to measure changes in intestinal gas production after supplementation of a complex fiber mixture over a 36 hour period in both lean normoglycemic individuals and individuals with insulin resistance and/or prediabetes with overweight when compared with a placebo Changes in intestinal gas production will also be related to energy expenditure, substrate metabolism, microbial composition and related metabolites in feces, blood and urine.

Clinical Trial Description

In this project the investigators aim to test whether it is possible to precisely measure the changes in fermentation gas patterns after supplementation of a complex fibre mixture over a 36-hour period in both lean normoglycemic and individuals with insulin resistance and/or prediabetes with overweight when compared with a placebo. Additionally, the investigators will investigate whether changes in fermentation patterns will be directly related to changes in carbohydrate and fat oxidation and to microbial composition or related metabolites and hormones in blood, faeces, and urine. ;

Study Design

Related Conditions & MeSH terms

Glucose Metabolism Disorders
Glucose Metabolism Disorders (Including Diabetes Mellitus)
Hyperinsulinism
Hypersensitivity
Insulin Resistance
Insulin Sensitivity
Metabolic Diseases

Clinical Trial Details

NCT number	NCT05764200
Study type	Interventional
Source	Maastricht University Medical Center
Contact	Gillian Larik, Msc
Phone	0433881641
Email	g.larik@maastrichtuniversity.nl
Status	Not yet recruiting
Phase	N/A
Start date	July 1, 2023
Completion date	October 31, 2025

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03458741` - How is Glycogen Supercompensation Regulated in Human Skeletal Muscle	N/A
Recruiting	`NCT06042517` - Mechanisms of Ultrasound Neuromodulation Effects in Diabetes	N/A
Completed	`NCT03859934` - Metabolic Effects of Melatonin Treatment	Phase 1
Completed	`NCT03689738` - Effects of Potato Resistant Starch Intake on Insulin Sensitivity, Related Metabolic Markers and Satiety	N/A
Recruiting	`NCT04195165` - The Effect of Sitting and Moderate Exercise on Plasma Insulin and Glucose Responses to an Oral Glucose Tolerance Test	N/A
Recruiting	`NCT05441982` - Saccharin and Acesulfame Potassium Consumption and Glucose Homeostasis in Older Adults With Prediabetes	N/A
Terminated	`NCT03325933` - Resistance Training and Cardiometabolic Health	N/A
Recruiting	`NCT05791968` - Blood Donation Could Improve Insulin Sensitivity	N/A
Completed	`NCT02913079` - The Acute Impact of Sit-stand Desks on Post-meal Blood Sugar Levels	N/A
Completed	`NCT02700698` - Mitochondrial Function in Circulating Cells and Muscle Tissue
Suspended	`NCT03240978` - Exercise Intervention for the Prevention of Prediabetes in Overweight Chinese	N/A
Recruiting	`NCT01972113` - Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study)	N/A
Completed	`NCT02058914` - Effects of Sugar Sweetened Beverage on Metabolic Health in Male and Female Adolescents	N/A
Enrolling by invitation	`NCT02192684` - Obesity, Sleep Apnea, and Insulin Resistance	N/A
Completed	`NCT00936130` - Bariatric Surgery and Weight Loss on Energy Metabolism and Insulin Sensitivity	N/A
Completed	`NCT01216956` - Metabolic Effects of an 8 Week Niaspan Treatment in Patients With Abdominal Obesity and Mixed Dyslipidemia	N/A
Recruiting	`NCT05992688` - The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)	N/A
Recruiting	`NCT04168372` - Fructose: Substrate, Stimulus, or Both?	N/A
Recruiting	`NCT05443347` - Activity, Adiposity, and Appetite in Adolescents 2 Intervention	N/A
Terminated	`NCT04239482` - Nutritional Supplementation and Insulin Sensitivity	N/A