Insulin Sensitivity Clinical Trial
Official title:
Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults
The investigators are studying the effects of Hyperglycemia on vascular function and insulin sensitivity on healthy adults
The investigators will study 22 healthy subjects (18-35 yrs) four times as follows: 1. Saline + Octreotide + euglycemia; 2. Octreotide + hyperglycemia; 3. Octreotide + hyperglycemia + insulin clamp and 4. Octreotide + Euglycemia + insulin clamp. The sequence of admissions will be assigned randomly. The investigators will assess function in conduit (pulse wave velocity-PWV, augmentation index-AI and flow-mediated dilation-FMD), resistance (post-ischemic flow velocity-PIFV) and heart and skeletal muscle microvascular (contrast enhanced ultrasound-CEU) vessels. This work will: a) identify whether vascular stiffness and indices of NO action are impaired throughout the arterial tree with hyperglycemia. ;
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