Type 2 Diabetes Affect Exercise Induced Improvement in Insulin Sensitivity

Insulin Sensitivity/Resistance Clinical Trial

— HIT  

Official title:

Does a Family History of Type 2 Diabetes Affect Exercise Induced Improvement in Insulin Sensitivity in a Hispanic Population?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02745613
• Other study ID #: 755513-1
• Status: Completed
• Phase: N/A
• Start date: April 2016
• Est. completion date: May 2019

Study information

• Verified date: January 2020
• Source: University of Texas, El Paso
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study investigates weather a family history of type 2 diabetes affects exercise induced improvements in insulin sensitivity in the hispanic population

Description:

A family history of T2D (FH+) is a risk factor for developing insulin resistance (which precedes T2D) and T2D (Ryder et al., 2003). Exercise training on the other hand has been shown to improve insulin sensitivity and is highly effective to prevent/manage T2D. However it is not known if early signs of insulin resistance appear before being clinically diagnosed and if the benefits of exercise which prevent/cure T2D, are limited to the offspring of Hispanic T2D parents. Therefore, the proposed study will determine 1) if normoglycemic (normal blood glucose) offspring of T2D parents are insulin resistant, using the gold standard method to measure insulin sensitivity and metabolic flexibility (ability to switch between carbohydrate and fat oxidation) 2) if 8 weeks of exercise training improves insulin sensitivity and metabolic flexibility to the same extent in FH+ compared to normoglycemic offspring of parents without any history of T2D (FH-) and 3) if 8 weeks of exercise training will change the blood, lipid and molecular profiles relevant to insulin sensitivity to same extent in FH+ compared to offspring of parents without family history of T2D (FH-).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: May 2019
• Est. primary completion date: May 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• 18 = Age = 40 years

• 18 = BMI = 30 kg/m2

• Both parents are Mexican/Mexican-American)

• Sedentary lifestyle

• Less than 60 minutes/wk. of structured exercise

• Physical activity level = 1.4

Exclusion Criteria:

• Evidence of significant cardiovascular disease or diabetes

• A fasting blood glucose =100 mg/dL

• Screening blood pressure >140/90

• Hyperlipidemia

• Use of drugs affecting energy metabolism or body weight

• Excess alcohol, drug abuse, and smoking

• Eating disorder or eating attitudes interfering with study

• Unwillingness to be abide by randomization

Related Conditions & MeSH terms

• Hypersensitivity
• Insulin Resistance
• Insulin Sensitivity/Resistance

Intervention

Other:
• 8 weeks of combined exercise intervention
The subjects will undergo an 8 week combined exercise intervention

Locations

Country	Name	City	State
United States	University of Texas at El Paso	El Paso	Texas

Sponsors (1)

Lead Sponsor	Collaborator
University of Texas, El Paso

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Insulin sensitivity		8 weeks
Secondary	Myokine concentrations		8 weeks