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Effects of Carnitine Supplementation on Liver and Muscle — ECLIPSE  

Insulin Resistance Clinical Trial

Official title:
Effect of Carnitine Supplementation on Liver Steatosis, Insulin Sensitivity, Plasma Glucose Homeostasis, Skeletal Muscle Metabolism and Energetics: a Pilot Study

Clinical Trial Summary

It will be evaluated whether carnitine, a dietary supplement, reduces liver fat and improves metabolism in individuals who have a high concentration of fat within their liver. Participants will be given either Carnitine or placebo, together with a meal replacement milkshake twice daily for 6 months.

Clinical Trial Description

NAFLD occurs when too much fat accumulates in liver tissue. This can, over time, cause inflammation and scarring of the liver, eventually leading to chronic liver disease and cirrhosis. It is strongly associated with diabetes and obesity, both of which are endemic in Western societies. Carnitine enables cells in the body to use fat as a fuel, and recent studies have suggested that carnitine supplementation may reduce liver triglyceride content. Muscle and liver are the major sites in the body which coordinate glucose and fat metabolism. As well as assessing the effect of carnitine supplementation on liver fat, its effect on metabolic processes within these tissues will also be measured ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03439917
Study type Interventional
Source University of Nottingham
Contact
Status Completed
Phase N/A
Start date April 2, 2018
Completion date November 1, 2021
View Details
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