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Effect of Fluvastatin on Brown Fat Activity — FluvaBAT  

Insulin Resistance Clinical Trial

Official title:
Short Term Effect of Fluvastatin on Brown Adipose Tissue Thermogenesis and Activity in Humans

Clinical Trial Summary

The purpose of this study is to elucidate the effects of Fluvastatin on brown adipose tissue activity in humans.

Clinical Trial Description

Statins, inhibitors of cholesterol biosynthesis, act by inhibiting the enzyme of the mevalonate pathway. Although the clinical benefits of statins are undisputable, they have been shown to increase insulin resistance and incidence of type 2 diabetes mellitus, the mechanism of which is currently not clear.

The main function of brown adipose tissue (BAT) is non-shivering thermogenesis (i.e. heat production through energy dissipation) in brown adipocytes. There has been a growing interest in BAT as a novel therapeutic approach to increase energy expenditure in order to facilitate weight-loss and increase insulin sensitivity.

BAT activity will be assessed using calorimetric test and [18F]-Fluorodeoxyglucose (FDG) positron emission tomography (PET).

We speculate that statins inhibit BAT function and that this mechanism may contribute to the above mentioned increase in insulin resistance. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03189511
Study type Interventional
Source University of Zurich
Contact
Status Completed
Phase Phase 4
Start date May 31, 2017
Completion date February 19, 2018
View Details
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