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The Effects of Altering Physical Activity on Cardiometabolic Health — PIA  

Insulin Resistance Clinical Trial

Official title:
The Effects of Altering Physical Activity on Endothelial Function, Glycemic Control, and the Blood Flow Response to an Oral Glucose Tolerance Test.

Clinical Trial Summary

The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters vascular health. Specifically, the investigators wish to examine in healthy, lean physically active individuals (obtaining greater than 10,000 steps/day) if decreasing physical activity (obtaining less than 5,000 steps/day) will alter blood flow following a meal a marker of vascular health. Furthermore, the investigators wish to examine if a one day return to physical activity (obtaining >10,000 steps/day) can restore the detrimental effects on blood flow following a meal.

Clinical Trial Description

Herein, we tested the hypothesis that an acute reduction in daily activity (from >10,000 to <5,000 steps/day) for 5 days in healthy individuals reduced meal-stimulated blood flow and if a 1 day return to activity improved this outcomes. ;

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01879059
Study type Interventional
Source University of Kansas Medical Center
Contact
Status Completed
Phase N/A
Start date March 2012
Completion date October 2014
View Details
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