Insulin Resistance Clinical Trial
Official title:
Effects of Preoperative Feeding With a Whey Protein Plus Carbohydrate Drink on the Acute Phase Response and Insulin Resistance.
Prolonged fasting may increase the organic response to trauma. Carbohydrate-based drinks have been tested and they may reduce insulin resistance. No study so far has aimed to examine the possible benefits of whey protein drink in the composition of preoperative drinks.
The patients will be randomized into two groups: the carbohydrate-protein group (CHO-P) and
the control group (CO). The patients will reeive a specific drink to their group on the
evening prior to surgery and three hours before the operation. The CHO-P group will receive
474 ml (evening drink) or 237 ml (3h prior to operation drink) of a solution containing 14%
whey protein (100% lactoalbumin), 86% carbohydrates (45% hydrolyzed corn starch and 55%
sucrose) and 0% lipids (Resource® Breeze - Nestlé, São Paulo, Brasil) and the CO group will
receive the same volume of water.
Outcome measures On the day of the surgery and on the first postoperative day blood samples
will be collected for glucose, insulin, triglycerides, albumin, pre-albumin, CRP, and
α-1-acid glycoprotein (α-1-GA) assays. HOMA-IR will be calculated
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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