Cassia Cinnamon for Glucose Uptake in Young Women

Insulin Resistance Clinical Trial

Official title:

Cassia Cinnamon and Acute Endurance Exercise for the Enhancement of Glucose Uptake in Healthy Young Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00951639
• Other study ID #: BaylorU_Cassia_Women
• Status: Completed
• Phase: N/A
• Start date: February 2008
• Est. completion date: May 2009

Study information

• Verified date: March 2022
• Source: Baylor University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study was to compare the acute effects of 5g of Cassia cinnamon, 50 minutes of endurance exercise performed at 70% of the heart rate reserve (correlated to VO2max), and 5g of cellulose placebo on blood glucose, serum insulin and insulin sensitivity following an oral glucose tolerance test 3 hours after administration of each intervention.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: May 2009
• Est. primary completion date: May 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Sedentary
• BMI: 27-45
• DXA body fat % greater than 30%
• 18-30 years of age
• Healthy
• From the Baylor University campus and surrounding community
• Regular sleep habits

Exclusion Criteria:

• Not regular users of any species of cinnamon
• Not diagnosed with any metabolic disorder or chronic medical condition
• Not taking prescription medications for 2 months before the study
• Not taking ergogenic aids for 2 months before the study
• Not taking oral contraceptives for 2 months before the study
• No IUD placed for 2 months before the study

Related Conditions & MeSH terms

• Glucose Intolerance
• Impaired Glucose Tolerance
• Insulin Resistance
• Prediabetes

Intervention

Dietary Supplement:
• Cassia cinnamon
5g encapsulated ground bark administered once in experimental session

Procedure:
• 50 minutes exercise
50 minutes treadmill endurance exercise at 70% of the heart rate reserve (correlated to VO2max)

Dietary Supplement:
• Cellulose Powder
5g encapsulated powder administered during placebo experimental session

Locations

Country	Name	City	State
United States	Baylor University Department of Health, Human Performance, and Recreation	Waco	Texas

Sponsors (1)

Lead Sponsor	Collaborator
Baylor University

Country where clinical trial is conducted

United States, 

References & Publications (4)

Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr. 2007 Jun;85(6):1552-6. — View Citation

Hlebowicz J, Hlebowicz A, Lindstedt S, Björgell O, Höglund P, Holst JJ, Darwiche G, Almér LO. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr. 2009 Mar;89(3):815-21. doi: 10.3945/ajcn.2008.26807. Epub 2009 Jan 21. — View Citation

Solomon TP, Blannin AK. Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans. Eur J Appl Physiol. 2009 Apr;105(6):969-76. doi: 10.1007/s00421-009-0986-9. Epub 2009 Jan 22. — View Citation

Solomon TP, Blannin AK. Effects of short-term cinnamon ingestion on in vivo glucose tolerance. Diabetes Obes Metab. 2007 Nov;9(6):895-901. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood Glucose		Baseline, 0, 30, 60, 90 and 120 minutes following OGTT
Secondary	Serum Insulin		Baseline, 0, 30, 60, 90 and 120 minutes following OGTT