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Chronic Insomnia and CSF Markers of Dementia - Effects of Treatment

Insomnia Chronic Clinical Trial

Official title:
Chronic Insomnia and CSF Markers of Dementia - Effects of Treatment

Clinical Trial Summary

The longstanding view has been that insomnia, and other forms of sleep disturbance, emerge as a consequence of dementia and are the result of progressive neuronal damage. However, there is growing evidence that the direction of causation may go both ways, with sleep disturbance potentially increasing vulnerability to dementia. Longitudinal studies have found that sleep disturbance often precedes and increases risk for dementia by several years. The purpose of this study is to examine whether treatment of insomnia with cognitive behavioral therapy (CBT-I) is associated with a decrease in dementia biomarkers found in cerebrospinal fluid (CSF). Fifteen adults age 30-50 with chronic insomnia will undergo overnight polysomnography and CSF sampling in the morning. This will be followed by 8 weeks of treatment with CBT-I and then repeat CSF sampling.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04073992
Study type Interventional
Source University of Pennsylvania
Contact
Status Completed
Phase N/A
Start date September 1, 2019
Completion date December 30, 2022
View Details
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