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NCT04952662 Clinical Trial

Candidate Gene Association Study With Injury in Elite Male Youth Football Players

Injuries Clinical Trial

Official title:
Candidate Gene Association Study With Injury, Non-Contact Injury, Non-Contact Muscle Injury, Fracture and Apophysitis Injury in Elite Male Youth Football Players

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04952662
Other study ID # SMEC_2019-20_002
Secondary ID
Status Completed
Phase
First received
Last updated
Start date December 1, 2019
Est. completion date May 31, 2021

Study information
Verified date July 2021
Source St Mary's University College
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Understanding how candidate genes, previously associated with injury susceptibility, influence the incidence of muscle, bone, ligament, and tendon injuries across the development pathway of elite footballers may provide valuable insight into inherent injury predisposition to support the long-term development of every individual. Therefore, the aim of the present study was to investigate the association between candidate genetic variants and muscle, bone, ligament, and tendon injuries in elite football with sub-analysis of the influence of age and maturation on injury susceptibility.

Description:

Genetic variants in several candidate genes which code for structural constituents (COL1A1 rs1800012, COL1A2 rs412777, COL5A1 rs12722 and ACTN3 rs1815739), regulatory components (ACE rs1799752, ESR1 rs2234693 and MMP3 rs679620) and transcription factors (VDR rs2228570 and GDF5 rs143383) affecting the form, function and injury susceptibility of muscle, bone, ligament, and tendon tissue will be associated with overall injury, non-contact, bone, ligament, tendon and apophysitis injury risk in elite male youth and adult footballers.

Recruitment information / eligibility
Status Completed
Enrollment 123
Est. completion date May 31, 2021
Est. primary completion date May 31, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 8 Years to 40 Years
Eligibility Inclusion Criteria: - Elite Male Footballer Player Registered at Fulham Football Club Exclusion Criteria: - Female no longer registered at Fulham Football Club

Study Design

Related Conditions & MeSH terms

Intervention

Genetic:
• Genetic variants
COL1A1 rs1800012, COL1A2 rs412777, COL5A1 rs12722, ACTN3 rs1815739, ACE rs1799752, ESR1 rs2234693, MMP3 rs679620, VDR rs2228570 and GDF5 rs143383

Locations
Country Name City State
United Kingdom Fulham Football Club London New Malden
United Kingdom St Mary's University, Twickenham London Twickenham

Sponsors (2)
Lead Sponsor Collaborator
St Mary's University College Fulham Football Club

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Number of non-injured and injured participants with injury risk alleles Injury, Non-Contact Injury, Non-Contact Muscle Injury, Fracture and Apophysitis Injury 8 Years
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