Influenza Clinical Trial
Official title:
Response to Inactivated Influenza Vaccine in Lymph Tissue and Blood
This is one project of a larger ongoing study related to the immune system's response to the flu virus. This study is designed to determine how immune memory develops at the actual site of exposure, and how immunization may alter this process.
This is a Phase IV study of licensed influenza vaccines with up to 50 volunteers, 20-75 years of age. Each volunteer will participate for approximately 1 week including enrollment, vaccination, and completion of sample collection. The study has a total of 3 visits. Study Procedures: Screening Visit: Procedures during this visit are: Informed consent process, assess eligibility collect relevant clinical data and obtain 10 mL of blood to ensure the FNA will be safe (acceptable CBC and PT/PTT). Visit 1: Vaccination Visit: Eligible subjects will return and have a 20 mL blood sample. Participants will receive the inactivated flu vaccine into the right anterior quadriceps. Volunteers will be monitored for at least 15 minutes after study vaccination. Visit 2: FNA Procedure: Seven days after vaccination the participant will return for another collection of 20 ml of blood and a fine needle aspiration of a right inguinal lymph node under ultrasound guidance by a trained pathologist. ;
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