Efficacy of MVA-NP+M1 in the Influenza H3N2 Human Challenge Model

Status Completed

Clinical Trial Summary

A Phase 2, single center, randomized, double blind study evaluating the safety, efficacy, and immunogenicity of MVA NP+M1 in the H3N2 human influenza challenge model; on healthy adult volunteers.

Clinical Trial Description

The study consists of an outpatient vaccination phase (155 participants), and at least 2 months later an inpatient challenge phase (134 participants). Participants are randomized 93:62 to receive either MVA-NP+M1 or Placebo. Up to 20 participants will be challenged over several 3-week blocks, and the remainder at the final 3-week block for a total of 80 MVA-NP+M1 and 54 Placebo recipients challenged. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03883113
Study type	Interventional
Source	Vaccitech Limited
Contact
Status	Completed
Phase	Phase 2
Start date	June 3, 2019
Completion date	April 17, 2020

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