Influenza Clinical Trial
Official title:
Project 1. The Role of CD4+ Memory Phenotype, Memory, and Effector T-Cells in Vaccination and Infection - Influenza-specific DR1501+ and DR0701+ T-cells
The purpose of this study is provide a better understanding of the adaptive immune response to the licensed flu vaccines. The investigators hope the information learned from this study will help identify and describe important factors of influenza immunity especially of or specific proteins associated with the T-cell immune response.
This is a study of up to 20 healthy monozygotic (MZ) twins (10 twin pairs), 18-49 years old,
that are participants from past Stanford-LPCH Vaccine Program trials and who have been
identified as human leukocyte antigen (HLA) DR1501+ or DR0701+ by lab assay results.
Volunteers will be contacted to assess interest in participating in this study. Both twins
in the pair must be willing to participate in the study. All participants will be randomized
within the twin pair to receive either the seasonal live, attenuated influenza vaccine
(LAIV) or the seasonal quadrivalent inactivated influenza vaccine (IIV4). Immunization will
be at Day 0, blood samples for immunogenicity assays will be collected prior to immunization
and at Days 7 (6-8) and 28 (24-32).
This study was halted due to the Advisory Committee on Immunization Practices against the
use of LAIV.
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