Influenza Clinical Trial
Official title:
The Human Mucosal Immune Responses to Influenza Virus: A Systems Biology Approach. Innate Immune Responses to Influenza Virus in Single Human Nasal Epithelial Cells
This study will examine the immune responses to the seasonal influenza vaccine in single cells of the nasal passages when compared with cells in circulating blood.
Using state-of-the-art technology, the investigators hope the information learned from this
study will help identify and describe important factors in the early-stage development of
influenza immunity and possibly lead to the development of more effective vaccines. This
study will be conducted in healthy male and female volunteers 18-30 years of age who
received one of two seasonal influenza vaccine types, intramuscular standard trivalent
inactivated influenza vaccine (TIV) or live, attenuated influenza vaccine (LAIV) given by
intranasal spray.
Participants are divided into two groups. The control group will receive the 2012-2013
formulation of the standard intramuscular trivalent inactivated influenza vaccine (TIV). A
blood sample and nasopharyngeal swab samples (one from each nostril) will be collected at a
single visit, Day 0. For those in the live, attenuated influenza vaccine (LAIV) group, at
the first visit, they will receive a single administration of the 2012-2013 formulation of
LAIV. At the second study visit two days later, they will provide a blood sample and two
nasopharyngeal swab samples (one from each nostril).
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