Evaluating Immune Response to Seasonal FluMist in Healthy Adults

Status Terminated

Clinical Trial Summary

The Live-Attenuated Influenza Vaccine (LAIV), also known as FluMist, has been shown to be effective in children but less effective in adults. Our hypothesis is that this relative failure is due to adults having enough anti-flu IgA antibody in nasal secretions to neutralize the weakened vaccine virus.

Clinical Trial Description

This is a VA-based study to evaluate serum and nasal wash antibody responses to seasonal LAIV of healthy Veterans and VA employees between the ages of 20 and 49 years old. Specific Aims 1. The primary aim of the study is to evaluate whether people with high mucosal IgA antibodies against flu have a lower immune response to the seasonal LAIV. 2. The secondary objective is to determine whether the nasal wash viral neutralization data predicts LAIV immunization failures. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01673425
Study type	Interventional
Source	National Center for Occupational Health and Infection Control
Contact
Status	Terminated
Phase	N/A
Start date	September 2012
Completion date	December 2012

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