Influenza Clinical Trial
Official title:
Comparison of Nylon Flocked Swabs and Saline Aspirates for Detection Respiratory Viruses
Collection of nasal secretions from infants and toddlers for viral testing is usually done using the nasal washing technique described by Hall in 1975. This is cumbersome. Previous attempts to use swabs have been unsuccessful because the swabs didn't work well. A newly designed swab may work better and in this study we compare the new swab with the old style nasal washing.
Collection of nasal secretions from infants and toddlers for viral testing is typically
performed using the nasal saline aspirate technique described by Hall in 1975.
Nylon flocked swabs (NFS) and universal transport medium for room temperature (UTM-RT) (Copan
Medical, Murrieta, CA) storage media have been found to be an effective collection and
transport method for bacteria causing sexually transmitted infections.
We adapted these swabs and storage medium to collect respiratory viruses from children less
than18 months old and compared detection rates using NFS and traditional nasal aspirates. We
will determine the relative roles of the UTM-RT and NFS release and therefore measured viral
detection rates of common respiratory pathogens in traditional saline aspirates stored in
UTM-RT.
Our primary hypothesis is that nasal secretions collection using NFS stored in UTM-RT will
lead to a higher detection rate of the respiratory viruses we arestudying; namely RSV,
Influenza and human metapneumovirus from than collection of unpreserved saline nasal
aspirates in children less than 18 months of age.
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