Influenza Clinical Trial
Official title:
Effectiveness of Influenza Vaccination (Alfarix)in Preventing Clinical Influenza Cases Among General Practitioners: Non-Randomized Clinical Trial.
Besides the personal protection, influenza vaccination especially needs to prevent transmission of influenza between GPs and their patients. The question remains if the vaccine is adding substantial benefit to the natural acquired immunity of GPs. Doubts are raised if an inactivated vaccine, which elicit especially humoral immune response, can give enough protection against virus replication and subclinical influenza infections. Until now no effectiveness studies of influenza vaccination were performed among GPs. This study will assess the effectiveness of an inactivated influenza vaccine in GPs against clinical respiratory tract infections and more particular against influenza cases with influenza positive nose and throat swabs (diagnosed by RT-PCR).
Two important aspects emerge when considering influenza vaccination of general practitioners
as advocated by many guidelines. Besides the personal protection the vaccine especially
needs to prevent transmission of influenza between GPs and their patients. In long-term
elderly hospitals a possible benefit of influenza vaccination of the healthcare workers was
noticed in reducing mortality among the elderly. But this specific situation is not fully
transmissible to the general practice.
GPs, having yearly close contact with several influenza cases, built up a high basic
immunity and probably only suffer from minor symptoms. The question remains if the vaccine
is adding substantial benefit to this natural acquired immunity. In addition doubts are
raised in the literature if an inactivated vaccine, which elicit especially humoral immune
response, can give enough protection against virus replication and subclinical influenza
infections. Until now no effectiveness studies of influenza vaccination were performed among
GPs. High time to look more closer to these issues.
Comparisons: the effectiveness of an inactivated influenza vaccine compared with no vaccine
in GPs against clinical respiratory tract infections and more particular against influenza
cases with influenza positive nose and throat swabs (diagnosed by RT-PCR), besides
serological defined influenza cases and taking important independent variables into account
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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