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Influenza, Human clinical trials

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NCT ID: NCT01867021 Completed - Influenza Clinical Trials

Immunogenicity, Safety and Tolerability of a Trivalent Subunit Inactivated Vaccine in Healthy Subjects 50 Years and Above

Start date: May 2013
Phase: Phase 4
Study type: Interventional

Demonstrate non-inferiority of the post-vaccination (Day 22) Hemagglutination inhibition (HI) Geometric Mean Titers (GMTs) of trivalent, inactivated, subunit influenza vaccine (TIV) over the corresponding GMTs of the comparator vaccine for all three strains, in healthy adults aged 50 years and above. Demonstrate non-inferiority of the percentages of subjects achieving seroconversion in antibody titers at Day 22 in the TIV group over the corresponding percentages of subjects in the comparator group for all three strains, in healthy adults aged 50 years and above.

NCT ID: NCT01863849 Completed - Clinical trials for Influenza Prophylaxis

Tolerability and Immunogenicity Study of Fluval AB Suspension for Injection

Start date: August 22, 2013
Phase: Phase 4
Study type: Interventional

To assess immunogenicity of a single intramuscular injection of Fluval AB suspension for injection (trivalent, seasonal influenza vaccine, active ingredient content: 15 μgHA/0.5mL of seasonal A/H1N1, A/H3N2 and B influenza antigens each), as measured by haemagglutination inhibition (HI) test.

NCT ID: NCT01863433 Completed - Influenza, Human Clinical Trials

A Study to Assess the Immunogenicity and Safety of a Trivalent Influenza Vaccine Containing the 2013/2014 Formulation of Enzira® Vaccine in Healthy Volunteers

Start date: May 2013
Phase: Phase 4
Study type: Interventional

This is a study to assess the immune (antibody) response and safety of a bioCSL split virion, inactivated influenza vaccine containing the 2013/2014 formulation of Enzira® vaccine in healthy adult volunteers aged between 18 and 60 years.

NCT ID: NCT01859143 Completed - Healthy Clinical Trials

Study to Evaluate the Safety of 3 New 6:2 Influenza Virus Reassortants in Adults

Start date: May 2013
Phase: Phase 4
Study type: Interventional

This prospective annual release study is designed to evaluate the safety on new influenza virus vaccine strains to be included in FluMist Quadrivalent for the 2013-2014 influenza season.

NCT ID: NCT01859039 Completed - Clinical trials for Egg Hypersensitivity

Safety of Nasal Influenza Immunisation in Egg Allergic Children

SNIFFLE
Start date: September 2013
Phase:
Study type: Observational

Egg allergy is common in early childhood, affecting at least one in 50 preschool children. Influenza ("'flu") vaccines contain egg protein, as the vaccine is cultured in hen's eggs. There is robust data to support the safety of influenza vaccines (containing low or negligible amounts of egg protein) in patients with egg allergy. A new influenza vaccine, known as LAIV (Live Attenuated Intranasal Vaccine) has recently been approved by a number of licensing boards and is given by a spray into the nose. This new vaccine has been available in the United States for several years and is highly effective and against influenza infection, with an excellent safety profile in children without egg allergy. However, LAIV is also grown in hen's eggs and contains egg protein, and there are NO existing data on the safety of LAIV in egg-allergic children. The objective of this multicentre study is to assess the safety of intranasal LAIV in egg-allergic children, in order to demonstrate that these children can safely be given the new LAIV within a primary care health environment.

NCT ID: NCT01857297 Completed - Influenza, Human Clinical Trials

A Study to Assess the Immunogenicity and Safety of CSL's 2013/2014 Formulation of Enzira® Vaccine in Healthy Volunteers

Start date: May 2013
Phase: Phase 4
Study type: Interventional

This is a study to assess the immune (antibody) response and safety of the 2013/2014 formulation of Enzira® vaccine in healthy adult volunteers aged 18 years or older.

NCT ID: NCT01857206 Completed - Influenza Clinical Trials

Safety of Two Trivalent Influenza Vaccines Evaluated in Children and Adolescents 4 to 17 Years of Age

Start date: May 2013
Phase: Phase 3
Study type: Interventional

Evaluate safety and tolerability of TIVa or TIVb vaccine in healthy children and adolescents 4 to 17 years of age.

NCT ID: NCT01855945 Completed - Clinical trials for Prophylaxis of A/H3N2v Influenza

Safety and Immunogenicity of Three Dosage Levels of Swine Influenza Vaccine in Children Ages 3 to <9 Years, Adolescents 9 to <18 Years, Adults 18 to <65 Years and Elderly 65 Years and Older.

Start date: May 2013
Phase: Phase 1
Study type: Interventional

Evaluate the safety and immunogenicity of three dosage levels of swine influenza vaccine in children ages 3 to <9 years, adolescents 9 to <18 years, adults 18 to <65 years and elderly 65 years and older.

NCT ID: NCT01854632 Completed - Influenza Clinical Trials

Clinical Efficacy of Trivalent Live-Attenuated Influenza Vaccine (LAIV) Among Children in Senegal

Start date: May 2013
Phase: Phase 3
Study type: Interventional

This study will provide the Senegal Ministry of Health with data on the clinical efficacy of the Live-Attenuated Influenza Vaccine (LAIV). This data will inform future policy considerations for influenza vaccine.

NCT ID: NCT01850446 Completed - Influenza Clinical Trials

Comparative Clinical Trial of Efficacy and Safety of Ergoferon Versus Oseltamivir in Treatment of Influenza

Start date: February 20, 2015
Phase: Phase 4
Study type: Interventional

The purpose of this study is: - to assess the efficacy of Ergoferon in treatment of influenza; - to assess the safety of Ergoferon in treatment of influenza; - to compare the efficacy of Ergoferon and Oseltamivir for treatment of influenza.