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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05039502
Other study ID # 2020-27194235-01
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date October 1, 2020
Est. completion date June 1, 2021

Study information

Verified date September 2021
Source Bulent Ecevit University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper Universal Retreatment (PTUR), Reciproc blue and XP-endo Finisher R file systems, which are used in the removal of root canal filling materials during retreatment with different motion kinetics on the release of Substance P, Calcitonin Gene-Related Peptide (CGRP), IL-6 and IL-10 inflammatory mediators in the periapical region


Description:

Seventy-five individuals with asymptomatic and chronic apical periodontitis teeth with retreatment indication were included in the study. Individuals were randomly divided into three groups according to the file system used to remove root canal filling materials (n = 25): ProTaper Universal Retreatment, Reciproc blue and XP-endo Finisher R.After the removal of the previous root canal filling materials, reshaping and disinfection of the root canals, periapical fluid samples were taken from the root tip of the teeth in all three groups. The amount of Substance P, CGRP, IL-6 and IL-10 mediators that cause pain, swelling and flare-up in periapical fluid samples were measured by ELISA test.


Recruitment information / eligibility

Status Completed
Enrollment 75
Est. completion date June 1, 2021
Est. primary completion date March 15, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 68 Years
Eligibility Inclusion Criteria: - Patients who had single root canal treated teeth with chronic periapical lesion Exclusion Criteria: - Patients who are immunocompromised - Patients under antibiotic or analgesic medication

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Protaper Universal Retreatment
D1-D2-D3 Retreatment files were used in 500 rpm and 3 Ncm with X-Smart endomotor
Reciproc
R25 retratment files were used with X-Smart endomotor in reciprocal motion
XP-Endo finisher R
XP-Endo finisher r file were used in 1000 rpm 1 Ncm with X-Smart endomotor

Locations

Country Name City State
Turkey Faculty of Dentistry of Bulent Ecevit University Zonguldak

Sponsors (1)

Lead Sponsor Collaborator
Bulent Ecevit University

Country where clinical trial is conducted

Turkey, 

Outcome

Type Measure Description Time frame Safety issue
Primary change of inflammatory mediator level The samples were collected from periapical exudate at the end of the root canal retreatment procedure. The samples were analyzed with ELISA method and change of inflammatory mediator levels were evaluated in pg/ml. 24 hours
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