Releasing of Inflammatory Mediators During Retreatment of Root Canals

Inflammatory Response Clinical Trial

Official title:

The Effect of Different File Systems Used in Retreatment on the Release of Inflammatory Mediators

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05039502
• Other study ID #: 2020-27194235-01
• Status: Completed
• Phase: N/A
• Start date: October 1, 2020
• Est. completion date: June 1, 2021

Study information

• Verified date: September 2021
• Source: Bulent Ecevit University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper Universal Retreatment (PTUR), Reciproc blue and XP-endo Finisher R file systems, which are used in the removal of root canal filling materials during retreatment with different motion kinetics on the release of Substance P, Calcitonin Gene-Related Peptide (CGRP), IL-6 and IL-10 inflammatory mediators in the periapical region

Description:

Seventy-five individuals with asymptomatic and chronic apical periodontitis teeth with retreatment indication were included in the study. Individuals were randomly divided into three groups according to the file system used to remove root canal filling materials (n = 25): ProTaper Universal Retreatment, Reciproc blue and XP-endo Finisher R.After the removal of the previous root canal filling materials, reshaping and disinfection of the root canals, periapical fluid samples were taken from the root tip of the teeth in all three groups. The amount of Substance P, CGRP, IL-6 and IL-10 mediators that cause pain, swelling and flare-up in periapical fluid samples were measured by ELISA test.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 75
• Est. completion date: June 1, 2021
• Est. primary completion date: March 15, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 68 Years

Eligibility

Inclusion Criteria:

• Patients who had single root canal treated teeth with chronic periapical lesion

Exclusion Criteria:

• Patients who are immunocompromised

• Patients under antibiotic or analgesic medication

Related Conditions & MeSH terms

• Inflammatory Response
• Root Canal Infection

Intervention

Other:
• Protaper Universal Retreatment
D1-D2-D3 Retreatment files were used in 500 rpm and 3 Ncm with X-Smart endomotor
• Reciproc
R25 retratment files were used with X-Smart endomotor in reciprocal motion
• XP-Endo finisher R
XP-Endo finisher r file were used in 1000 rpm 1 Ncm with X-Smart endomotor

Locations

Country	Name	City	State
Turkey	Faculty of Dentistry of Bulent Ecevit University	Zonguldak

Sponsors (1)

Lead Sponsor	Collaborator
Bulent Ecevit University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change of inflammatory mediator level	The samples were collected from periapical exudate at the end of the root canal retreatment procedure. The samples were analyzed with ELISA method and change of inflammatory mediator levels were evaluated in pg/ml.	24 hours