Intracranial Aneurysm Clinical Trial
Official title:
Application of Atorvastatin in the Treatment of Patients With Intracranial Unruptured Aneurysms
This study was designed to identify whether there is a measurable reduction in inflammation in walls of intracranial aneurysms with oral atorvastatin.
Unruptured intracranial aneurysms (UIAs) are increasingly detected and often remain
clinically asymptomatic for a long time before rupture. However, once the UIAs ruptured, the
incidence of mortality rate varies from 30% to 60% within 6 months. Thus, the risk of UIAs
rupture should be weighed, and need an individual criterion for predicting rupture in
clinical decision making.
Histopathological studies indicated that inflammation may play an important role in the
formation, growth, and rupture of UIAs. Wall enhancement of a saccular aneurysm on high
resolution magnetic resonance (HRMRI) is a proven sign of inflammatory change and might
predict an unsteady state of an intracranial saccular aneurysm.
Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase and are established
first-line treatments for hypercholesterolemia. Statins produce a range of pleiotropic
effects in addition to inhibition of cholesterol synthesis, especially to reduce
inflammation, which may be important in reducing the growth and rupture of UIAs.
In the study, participants known to have UIA that is not planned for treatment and has not
yet ruptured, take atorvastatin daily for six months, and have an HRMRI scan before and after
to look for the role of atorvastatin in inflammation.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04870047 -
Coating to Optimize Aneurysm Treatment In The New Flow Diverter Generation
|
N/A | |
| Recruiting |
NCT05968053 -
Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)
|
||
| Not yet recruiting |
NCT05665309 -
Interest of Pre-operative Use of 3D Printing for Endovascular Treatment of Unruptured Intracranial Aneurysms With Intrasaccular Flow Disruptor
|
N/A | |
| Completed |
NCT02783339 -
Neuroform Atlas Stent for Intracranial Aneurysm Treatment
|
||
| Withdrawn |
NCT01194388 -
Axium Coil in Completing Endovascular Aneurysm Surgery Study
|
||
| Completed |
NCT00071565 -
Familial Intracranial Aneurysm Study II
|
N/A | |
| Recruiting |
NCT05409989 -
MicroVention, Inc. Flow Re-Direction Endoluminal Device X (FRED™ X™) Post-Approval Study
|
N/A | |
| Completed |
NCT03680742 -
Contour Neurovascular System - European Pre-Market Unruptured Aneurysm
|
N/A | |
| Completed |
NCT04872842 -
Establishment of Online Registration Platform for Unruptured Intracranial Aneurysms Based on 100 Regional Medical Centers in China and Population Follow-up Study
|
||
| Terminated |
NCT02532517 -
Study to Evaluate the Safety and Effectiveness of the CODMAN ENTERPRISE® Vascular Reconstruction Device
|
N/A | |
| Completed |
NCT03663257 -
Study to Evaluate Cerebral AneurysmFlow Results in Occlusion
|
||
| Recruiting |
NCT06189950 -
Registration Trial of the Intracranial Visualized Stent for the Wide-necked Intracranial Aneurysms:REBRIDGE
|
N/A | |
| Recruiting |
NCT05608122 -
Establishment of Online Registration Platform for Unruptured Intracranial Aneurysms Based on Regional Medical Centers in China and Population Follow-up Study (Phase Ⅱ)
|
||
| Recruiting |
NCT03661463 -
Unruptured Intracranial Aneurysm Aspirin Trial (UIAAT).
|
Phase 2 | |
| Completed |
NCT02609867 -
A Feasibility Study to Evaluate the Safety and Effectiveness of Implantation of Flowise Cerebral Flow Diverter (Flowise)
|
N/A | |
| Active, not recruiting |
NCT02292017 -
Prospective Packing Density With Target Coils I
|
N/A | |
| Active, not recruiting |
NCT01872741 -
Minipterional Versus Pterional Craniotomy
|
N/A | |
| Completed |
NCT00993057 -
Efficiency of Two Glucose Sampling Protocols for Maintenance of Euglycemia
|
Early Phase 1 | |
| Completed |
NCT00777088 -
Pipeline for Uncoilable or Failed Aneurysms
|
N/A | |
| Completed |
NCT00777907 -
Complete Occlusion of Coilable Aneurysms
|
Phase 3 |