Markers in Follicular Fluid and in Embryo Culture Medium as a Marker of Oocyte and Embryo Quality

Infertility/Sterility Clinical Trial

Official title:

Markers in Follicular Fluid and in Embryo Culture Medium as a Marker of Oocyte and Embryo Quality

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT03350009
• Other study ID #: CMC-16-0163-CTIL
• Status: Enrolling by invitation
• Start date: December 11, 2017
• Est. completion date: November 2019

Study information

• Verified date: January 2019
• Source: Carmel Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Assessment of the quality of follicular fluid and early embryo via chemical markers.

Description:

The selectin of an embryo for transfer is currently based on detailed morphological assessment and scoring system. morhpokinetics introduced recently to IVF laboratories can define annotations and provide an algorithm for optimal cleavage rates and embryonic development. however more data and validations are requested when it comes to choosing the best single embryo from a cohort of available similarly graded embryos. Consequently, non-invasive quantitative methods for embryo selection prior to transfer have been sought. In the current study metabolic profile of follicular fluid and the embryos produced in IVF procedure will be assessed

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 220
• Est. completion date: November 2019
• Est. primary completion date: June 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Patients undergoing IVF procedures at Carmel Medical Center and are able to sign an informed consent form.

• Female patients age 18-45

Exclusion Criteria:

• Women with any malignancy

• Patient's request to be withdrawn from the study.

Related Conditions & MeSH terms

• Infertility
• Infertility/Sterility

Locations

Country	Name	City	State
Israel	Carmel Medical Center	Haifa

Sponsors (1)

Lead Sponsor	Collaborator
Carmel Medical Center

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Different markers discriminating the studied groups.	High correlation between the studied markers and the currently used morphological assessment of the quality of embryos and oocytes will define the potential of the studied markers as a mean for embryo and quality assessment.; The current study is pioneer in the field of assessment of embryos and follicles and this group of markers have not been studied previously, therefore we prefer not to clarify more details	two years