Infertility Indicated for ICSI Clinical Trial
Official title:
Role of Aromatase Inhibitor to Enhance Ovulation in Poor Responder During Induction With Short Antagonist Protocol in Cases of ICSI(Intracytoplasmic Sperm Injection) a Case Control Study
study the effect of aromataze inhibitor induction together with short stimulation protocol by gonadotrphin releasing hormon antagonist in cases that expected to be poor responder before ICSI
This is a prospective randomized case control study will be conducted in Maternity hospital
IVF unite Minia University after being approved by local ethical committee of obstetrics and
gynecology department faculty of medicine, all study details will be explained to patients
and informed consent will be obtained before inclusion in the study . enrolled patients will
be randomized into two groups using simple randomization by sealed opaque envelops contain
serial computer generated numbers Control group will receive HMG 300 IU daily start at first
day of menses with follow up by trans vaginal ultrasound (TVUS ) when at least three
follicles reach 14mm diameter GnRh antagonist given 0.1 ml continue follow up when at least
three follicles reach 17mm in diameter ovum pickup will done under TVUS guide if less than
three follicles cycle will be cancelled .
Study group will receive same management plus letrozole 2.5mg daily start at the first day of
menses for 5 days and continue with same protocol
;