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NCT05755529 Clinical Trial

Effects of Low LH Serum Levels on Ovarian Pick-up Outcome

Infertility, Female Clinical Trial

Official title:
Effects of Low LH Serum Levels on Oocyte Retrieval, Fertilization Rate and Embryo Quality During Controlled Ovarian Stimulation: Results From a Prospective Cohort Analysis

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05755529
Other study ID # LH-OS-1
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date March 2023
Est. completion date March 2023

Study information
Verified date March 2023
Source University of Palermo
Contact Andrea Etrusco, M.D.
Phone +39 3881715032
Email etruscoandrea@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Luteinizing hormone (LH) plays a key role for normal follicular development and oocyte maturation in controlled ovarian stimulation. In particular, LH stimulates the proliferation and differentiation of theca cells for the secretion of androgens, which synergistically increase the production of estrogen. This study aimed to investigate the effects of low LH concentrations on oocyte retrieval, fertilization and embryo development in patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Patients undergoing IVF/ICSI were prospectively analyzed, subdividing them into three groups according to their age. Serum LH levels were evaluated at day 3, during stimulation (day 10) and before ovulation induction (day 12).

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 43
Est. completion date March 2023
Est. primary completion date March 2023
Accepts healthy volunteers No
Gender Female
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria: age between 18 and 40 years, body mass index 18-29 kg/m 2 , regular menstrual cycles, normal uterine cavity assess by hysteroscopy, normal uterus and ovaries at transvaginal sonography, Exclusion Criteria: abnormal cervical cytology, affected by any other endocrinological, metabolic, autoimmune, and gynecological disease.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
University of Palermo

Outcome
Type Measure Description Time frame Safety issue
Primary Oocyte retrieval number of retrieved oocytes after controlled ovarian stimulation immediately after the intervention
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