Preoperative Anxiety at Oocyte Retrieval

Infertility, Female Clinical Trial

Official title:

The Effect of Preoperative Anxiety With Depth of Anesthesia During Oocyte Retrieval on IVF Success

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03134651
• Other study ID #: TUTF-GOKAEK 2014/115
• Status: Completed
• Phase: N/A
• First received: March 30, 2017
• Last updated: April 25, 2017
• Start date: July 24, 2014
• Est. completion date: September 24, 2016

Study information

• Verified date: April 2017
• Source: Trakya University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study evaluated the effects of preoperative anxiety and dosage of anesthesia on IVF success. Half of participants according to the recorded Beck's Anxiety Inventory (BAI) score: a low-anxiety group, while the other half high-anxiety group.

Description:

Anxiety is common among women hospitalized for oocyte retrieval. Infertility is usually accompanied by psychological and behavioral changes and can result in preoperative anxiety. Sometimes, preoperative anxiety can be serious. Furthermore, in the absence of premedication for oocyte retrieval, severe degrees of anxiety may occur. Anxiety effects the total consumption of analgesic and anesthetic drugs intraoperatively and has a negative impact on recovery from anesthesia. In addition, the negative effect of anesthetic agents used on fertilization and embryo quality during in vitro fertilization (IVF) has been discussed. However, the impact of any of them on fertilization and embryo quality has not been clearly determined to date. Studies have reported different results regarding the negative effects of anesthetic agents on embryo development and fertilization.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 131
• Est. completion date: September 24, 2016
• Est. primary completion date: July 24, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 25 Years to 43 Years

Eligibility

Inclusion Criteria:

• oocyte retrieval under sedation

• 25 and 43 years of age

• American Society of Anesthesiologists physical status I-II

Exclusion Criteria:

• history of psychiatric illness

• secondary infertility can be surgically corrected

• not able to communicate well in the native language

• those women who necessitated general anesthesia

Related Conditions & MeSH terms

• Anesthesia Awareness
• Anxiety Disorders
• Anxiety State
• Infertility
• Infertility, Female
• Intraoperative Awareness

Intervention

Device:
• Monitoring brain function

Drug:
• propofol

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Trakya University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in perioperative Monitoring brain function were measured	Monitoring brain function was assessed Change from baseline at preoperatively, intraoperative 5th and 15th minutes and after anesthesia	Preoperative, intraoperative and postoperative first minute
Secondary	pregnancy rate	pregnancy rate	10 days