Infectious Diseases Clinical Trial
Official title:
Comparative Study of 2% Chlorhexidine Gluconate in 70% Isopropyl Alcohol Against 10% Sodium Hypochlorite as Skin Antiseptics in Human Volunteers
The physicians have few options for skin antisepsis. Alternatives for common use antiseptics are costly or ineffective. In order to have more options, this study is needed. The investigators want to know if there are differences between the use of 2% chlorhexidine gluconate in 70% isopropyl alcohol or 10% sodium hypochlorite.
Sodium hypochlorite at 10% has been widely used as antiseptic in patients on dialysis as
well as for irrigation of wounds and burns. Since it has been used successfully in caring
for the exit side of hemodialysis catheters, it is reasonable to propose its use for the
insertion and care of central intravascular catheters, as well as for skin preparation
before surgery. Alternatives for povidone-iodine, which is the agent most commonly used, are
costly or ineffective. In a recent study perform by our group it was demonstrated that 10%
sodium hypochlorite was not inferior than povidone-iodine.
It has been demonstrated as well that 2% chlorhexidine gluconate in 70% isopropyl alcohol is
superior to povidone-iodine. The aim of this study is to know if 10% sodium hypochlorite has
a similar effect that the best current option for skin antisepsis.
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Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
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