Infection, Bacterial Clinical Trial
Official title:
Performance Assessment of 7 Biomarkers for the Diagnosis of Severe Bacterial Infections in Children Aged From 7 Days to 36 Months.
ANTOINE is a prospective trial which aims to assess diagnostic performance of 7 biomarkers
for the diagnosis of severe bacterial infections (SBI) in children aged from 7 days to 36
months.
Fever is a frequent cause of consultation in pediatric emergency departments. Clinical
diagnostic tools are rare and discrimination between severe bacterial infection and viral
infection is difficult to confidently state. The prevalence of severe bacterial infections
(IBS) varies from 10 to 25% according to the studies. Biological markers such as
procalcitonin (PCT) and C-reactive protein (CRP) are commonly used in clinical practice.
These markers have bacterial specificity but share a wide range of values with viral
infections and do not make it possible to exclude or to confirm definitively the diagnosis of
IBS. The use of new markers to improve the diagnosis of bacterial and viral infections is
increasingly studied in adults. The diagnostic value of these new markers has been
demonstrated by associating their dosage with that of CRP for example. This is the case for
IP-10, TRAIL or MxA. However, very few pediatric studies have been carried out to date on
these new biomarkers. However, in pediatrics, these diagnostic tools based on the combination
of biomarkers to discriminate against viral and bacterial infections could be a major help in
the suspicions of IBS. 7 biomarkers were selected to be evaluated in this study. This study
is designed to determine the best biomarkers combination for the SBI diagnosis on a cohort of
800 patients.
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