Infection Systemic Clinical Trial
Official title:
Prognostic Value of Complete Blood Count in Children Suffering of Severe Infections in Pediatric Care Unit
Sepsis is a leading cause of hospitalization in pediatric intensive care units, In the last decade, a series of initiatives were implemented that aim not only to improve the understanding of sepsis and the clarity of concepts related to this condition but also to reduce morbidity and mortality due to sepsis through earlier diagnosis and initiation of antibiotic therapy as well as through the provision of specific guidelines for the treatment of pediatric sepsis. Despite these measures and the lower mortality from sepsis in children compared to adult patients, the impact of sepsis in the pediatric population remains high.
According to the World Health Organization, sepsis remains a leading cause of death in
infants and children in developed and developing countries.Some prognostic scoring systems
with performance status, clinical symptoms, and biochemical parameters help to guide accurate
prediction of the prognosis, such as the acute physiology and chronic health evaluation
(APACHE), yet are considered too complex for general clinical use. Therefore, the prediction
of clinical events with laboratory parameters, including complete blood cell count (CBC), has
become an increased focus of research.
Accumulating evidence indicates that the CBC is an effective predictor of prognosis and
mortality in many disease states, including hematological disease, neoplasms, and diseases of
the circulatory system severe infections. Therefore, nonspecific changes in the CBC in
critically ill patients could be considered a key prognostic factor in the evaluation of
survival prediction in these patients .
According , it is possible that the CBC could be used as a predictor of survival in severe
infections patients. The complete blood count (CBC) , a five-cell automated differential
count and a reflex manual differential count (when required by protocol) and is one of the
most frequently ordered admission laboratory tests.
In practice, it is a routine ingredient of all hospital admission orders - a complete blood
count is done for our medical , surgical admissions and the same is true at most institutions
. it is known that the white blood cell count do predict disease severity and mortality risk.
For example, elevated WBC counts predict a worse prognosis in patients with severe infections
in pediatric intensive care unit ,Further, this test provides direct management guidance in
common circumstances, e.g., infection.
The CBC describes the number and morphology of over 40 different cells. Disagreement exists
regarding the clinical significance of many of these observations. And only a few components
of the manual differential, e.g., nucleated red blood cells and lymphocytes, have been
quantitatively evaluated to determine their prognostic significance. But these two
observations have not been examined to determine their independent contributions to mortality
predictions when taken in conjunction with their accompanying CBC observations. .
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02987790 -
Duration of Antibiotic Therapy in Critically Ill Patients: C-reactive Protein-guided Therapy Versus Best Practice
|
N/A |