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Persistent Pulmonary Hypertension of the Newborn (PPHN) Observational Study — PPHN  

Infant, Premature Clinical Trial

Official title:
Persistent Pulmonary Hypertension of the Newborn (PPHN) Observational Study

Clinical Trial Summary

This study was an observational study to estimate the prevalence of Persistent pulmonary hypertension of the newborn (PPHN) among term or near-term infants with severe respiratory disease.

Clinical Trial Description

The optimal approach to the treatment of PPHN remains controversial. In 1978, hyperventilation was advocated for the treatment of PPHN. Newer therapies such as alkali infusion have been introduced without the support of randomized trial. In addition, in 1993, large controlled trials of inhaled nitric oxide were in the planning stages. There is a lack of knowledge about how these diverse management styles impact patient outcome.

Given the large number of treatments used in neonates with PPHN, we wished to document treatment of PPHN and outcomes of those treatments. Therefore, we performed a prospective, observational study to document prevalence of PPHN, the treatments and outcomes in a large population of infants treated at the 12 centers of the National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. Further, we sought to compare treatment with hyperventilation to treatment with alkali infusion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01203423
Study type Observational
Source NICHD Neonatal Research Network
Contact
Status Completed
Phase
Start date October 1993
Completion date December 1994
View Details
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