Clinical Trials Logo

Infant, Newborn clinical trials

View clinical trials related to Infant, Newborn.

Filter by:

NCT ID: NCT01380886 Completed - Infant Newborn Clinical Trials

Growth and Tolerance of Young Infants Fed Infant Formulas

Start date: June 2011
Phase: Phase 3
Study type: Interventional

This is a randomized, multi-center, double blind, parallel study to compare growth and tolerance of healthy term infants fed either control or experimental infant formula.

NCT ID: NCT01300000 Completed - Infant Newborn Clinical Trials

Effects of Early Nutrition on Growth

Start date: March 2010
Phase: N/A
Study type: Interventional

The primary objective of the study is to compare the growth of infants fed standard infant formula with infants fed a reduced calorie and protein formula.

NCT ID: NCT01223287 Completed - Infant, Premature Clinical Trials

Physiologic Definition of Bronchopulmonary Dysplasia

PhysiologicDef
Start date: May 2005
Phase: N/A
Study type: Observational

This observational study was conducted to design and test a physiologic definition for bronchopulmonary dysplasia at 36 weeks of life. Infants were studied in a supine position with the pulse oximeter in position with good signal prior to collecting baseline data. Feedings and medications were given 30 minutes before the evaluation. Baseline data was collected on infant's current oxygen. Then, the infants were weaned to room air for 30 minutes. If saturations remain ≥90%, the infant was considered to have passed the oxygen reduction challenge (to NOT have BPD). The infant should then be placed back in his/her baseline oxygen. If the infant has saturations <90% for 5 continuous minutes or <80% for 15 seconds, the infant should be immediately placed back in his/her baseline oxygen, and the infant was considered to have NOT passed the challenge (to have BPD).

NCT ID: NCT01223274 Completed - Clinical trials for Bronchopulmonary Dysplasia

Delivery Room CPAP in Extremely Low Birth Weight Infants

DR-CPAP
Start date: July 2002
Phase: Phase 1/Phase 2
Study type: Interventional

This pilot study was designed to determine the feasibility of randomizing extremely low birth weight (ELBW) infants <28 weeks' gestation who required resuscitation to one of two resuscitation methods, either: (a) 100% oxygen by facemask and continuous positive airway pressure (CPAP) or positive pressure ventilation (PPV) with positive end-expiratory pressure (PEEP), if the infant required PPV (the intervention group); or (b) 100% oxygen and no CPAP and no PEEP if the infant required PPV (the control group).

NCT ID: NCT01223261 Completed - Infant, Premature Clinical Trials

Observational Study of Surgical Treatment of Necrotizing Enterocolotis

NEC Surgery
Start date: March 2001
Phase:
Study type: Observational

The purposes of this study were: 1) to compare mortality and postoperative morbidities in extremely low birth weight (ELBW) infants who underwent initial laparotomy or drainage for necrotizing enterocolitis (NEC) or isolated intestinal perforation (IP); 2) to determine the ability to distinguish NEC from IP preoperatively and the importance of this distinction on outcome measures; and 3) to evaluate the association between extent of intestinal disease determined at operation and outcome measures. All ELBW infants born at participating NRN centers were screened for the presence of NEC or IP that was thought by the pediatric surgeon and neonatologist to require surgical intervention. Data were collected enrolled infants, including: intraoperative findings recorded by the surgeon and specific post-operative complications. Neurodevelopmental examinations were conducted on surviving infants at 18-22 months corrected age.

NCT ID: NCT01222364 Completed - Infant, Premature Clinical Trials

Delayed Cord Clamping in VLBW Infants

Start date: June 2000
Phase: Phase 1/Phase 2
Study type: Interventional

This study tested the feasibility of conducting a randomized controlled trial to vary the timing that doctors clamp the umbilical cord after birth in extremely low birthweight infants. The study also tested whether delaying cord clamping by 30-35 seconds and holding the newborn approximately 10 inches below the birth canal would result in increased hematocrit at 4 hours of age.

NCT ID: NCT01203514 Completed - Infant, Premature Clinical Trials

The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Very Low Birth Weight Infants

EPO
Start date: August 1997
Phase: Phase 2/Phase 3
Study type: Interventional

This study tested the safety and efficacy of transfusing erythropoietin (Epo) and iron in infants of <1,250g birth weight. For infants 401-1,000g birth weight, we tested whether early erythropoietin (Epo) and iron therapy would decrease the number of transfusions received. For infants 1,001-1,250g birth weight, we tested whether early erythropoietin (Epo) and iron therapy would decrease the percentage of infants who received any transfusions.

NCT ID: NCT01203501 Completed - Cerebral Palsy Clinical Trials

In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight Infants

MgSO4
Start date: July 1996
Phase: N/A
Study type: Observational

This study examined the effect of magnesium sulfate (MgSO4) exposure on adverse outcome in extremely low birth weight (ELBW) infants. For infants included in the NICHD Neonatal Research Network Generic Database whose mothers were given prenatal MgSO4, data were prospectively collected on maternal/infant conditions and magnesium exposure (including indications, timing and duration of exposure).

NCT ID: NCT01203488 Completed - Sepsis Clinical Trials

Vitamin A Supplementation for Extremely-Low-Birth-Weight Infants

Vitamin A
Start date: January 1996
Phase: Phase 1/Phase 2
Study type: Interventional

This multi-site, randomized trial was conducted to determine the safety and effectiveness of a higher dose of vitamin A and determine if this would increase the rate of survival without bronchopulmonary dysplasia (BPD) and reduce the risk of sepsis. Infants with birth weights from 401-1000g and who were on mechanical ventilation or supplemental oxygen at 24-96 hours of age were enrolled. Subjects were randomized to either the Vitamin A or a control group. Infants in the Vitamin A group were given a dose of 5000 IU (0.1 ml) intramuscularly on Mondays, Wednesdays, and Fridays for four weeks. Control infants received a sham procedure rather than placebo injections.

NCT ID: NCT01203475 Completed - Infant, Premature Clinical Trials

Growth Observational Study

Growth
Start date: August 1994
Phase: N/A
Study type: Observational

This study was a multicenter, prospective cohort study to define postnatal longitudinal growth for very low birth weight (VLBW) infants. The objectives were: 1) to develop postnatal growth curves for VLBW preterm infants that would permit an assessment of growth velocity; 2) to relate growth velocity and nutritional practices (duration of parenteral nutrition, age at first enteral feeding, and age at full enteral feeding); 3) to compare growth velocity in infants who are small-for-gestational age (SGA) with infants who are appropriate-for-gestational age (AGA); and 4) to relate growth velocity to several common, major morbidities, including chronic lung disease (CLD), nosocomial infection (or late-onset infection) and necrotizing enterocolitis (NEC). These growth data may be useful in identifying preterm infants who are growing slowly despite current nutritional support and in designing and performing clinical trials of nutritional interventions.