Induction of Labor Affected Fetus / Newborn Clinical Trial
Official title:
NITROGLYCERINE SKIN PATCH VS PLACEBO PATCH FOR ENHANCING CERVICAL RIPENING IN LABOR INDUCTION: A RANDOMIZED CONTROLLED TRIAL
This study aims to establish the efficacy of transdermal glyceryl trinitrate as a nitric oxide donor in addition to dinoprostone for induction of cervical ripening in the third trimester through progression in the Bishop's score during 24 hour period.
Objectives: The primary outcome of the study is to compare the changes occurring to the
cervix through the progression in the Bishop's score between NO donor (nitroglycerine patch)
vs placebo; in combination with a well-established method of induction (Dinoprostone).
The secondary objective of the study is to observe and report possible fetal and maternal
side effects that may be associated. This will establish the safety and tolerability of NO
donors.
Research Question: Does the usage of Nitroglycerine skin patch enhance cervical ripening and
facilitate induction of labor by Dinoprostone?
Null hypothesis: Nitroglycerine skin patch does not cause advantage for ripening of the
cervix nor facilitate the process of labor induction.
Alternative hypothesis : Nitroglycerine skin patch has favorable effect in enhancing cervical
ripening and the outcome of induction of labor.
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