What Amount of Stress is Enough for a Successful Conception?

Status Recruiting

Clinical Trial Summary

The aim of the study is to determine whether premedication with midazolam before oocyte aspiration in IVF procedures affects the amount of (oxidative) stress in women undergoing IVF and whether stress is also transmitted to the follicular fluid of aspirated follicles. The primary endpoint is the impact of stress during aspiration on the success of medically assisted fertilization (IVF / ICSI in the stimulated cycle).

Clinical Trial Description

The procedure of in vitro fertilisation (IVF) is used to treat the infertility problems. The procedure includes ovary aspiration, to isolate oocytes. During the aspiration the patient is sedated with short-term intravenous aesthetic. Premedication is often used in anaesthesiology, and includes drugs application 30 minutes prior to procedure to sedate and treat the anxieties of the patient. One of the most often used drugs in premedication is midazolam. As the procedure is quite stressful for the patients, our aim is to investigate the influence of midazolam premedication on the stress release during the oocyte aspiration procedure, as well as its influence on the whole IVF procedure. Therefore, patients will be divided into two groups, control and midazolam. Blood samples will be taken before and during the procedure. Stress, antioxidant parameters (with glutathione and catalase) and oxidative status will be monitored in serum and follicular fluid.

The results will be correlated with subjective stress levels in the two groups in an effort to establish ties with IVF results. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04160611
Study type	Interventional
Source	University Hospital "Sestre Milosrdnice"
Contact	Andro Košec, MD, PhD
Phone	+385989817156
Email	andro.kosec@yahoo.com
Status	Recruiting
Phase	Phase 3
Start date	September 1, 2019
Completion date	October 1, 2020

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05130944` - Feasibility of Community Psychosocial Intervention for Women	N/A
Recruiting	`NCT06079853` - Nurse Suicide: Physiologic Sleep Health Promotion Trial	N/A
Completed	`NCT05881681` - A Mindfulness Approach to UA for Afro-descendants	N/A
Recruiting	`NCT05449002` - Digital Single Session Intervention for Youth Mental Health	N/A
Recruiting	`NCT04038190` - A Behavioral Activation Intervention Administered in a College Freshman Orientation Course	Phase 2
Completed	`NCT03931772` - Online Automated Self-Hypnosis Program	N/A
Active, not recruiting	`NCT05998161` - Evaluating the Effectiveness of a Digital Therapeutic (Reviga) for People With Stress or Burnout	N/A
Completed	`NCT03728062` - Mindfulness Meditation Versus Physical Exercise: Comparing Effects on Stress and Immunocompetence	N/A
Terminated	`NCT04367636` - The Effects of Attention Training on Emotion Regulation and Stress Related Complaints During COVID-19	N/A
Completed	`NCT06405789` - The Effect of Yoga on Mindfulness and Perceived Stress	N/A
Recruiting	`NCT06002074` - SMART Program Impact on Quality of Life in Inflammatory Bowel Diseases	N/A
Recruiting	`NCT05273996` - Predictors of Cognitive Outcomes in Geriatric Depression	Phase 4
Completed	`NCT05245409` - Stress, EEG, ECG, and Chiropractic	N/A
Completed	`NCT04722367` - Being Present With Art: The Impact of Mindful Engagement With Art on Awareness and Connection	N/A
Recruiting	`NCT06273228` - Parenting Young Children in Pediatrics	N/A
Completed	`NCT06057883` - Effects Of A Probiotic Formulation On Stress and Skin Health in Younger Adult Females	Phase 2
Completed	`NCT05063305` - Probiotics, Immunity, Stress, and QofL	N/A
Completed	`NCT05312749` - The Effect of Web Based Progressive Muscle Relaxation Exercise on Clinical Stress and Anxiety of Nursing Students	N/A
Completed	`NCT05623826` - Feasibility and Efficacy of a Digital Training Intervention to Increase Reward Sensitivity- Imager	N/A
Completed	`NCT04013451` - The Kiss of Kindness Study II	N/A