Infertility Clinical Trial
Official title:
Prospective Randomized Controlled Trail to Assess the Efficacy of EmbryoGen Culture Medium to Improve Ongoing Pregnancy and Implantation Rates in IVF Treatments of Patients With a Previous History of Implantation Failure
Recently, it has been suggested that culture of embryos in EmbryoGen medium can increase the
live birth rate in IVF patients with a previous history of pregnancy loss.
Couples requiring IVF treatment and with a past experience of implantation failure will be
included in the study.
Controlled ovarian stimulation protocol will consist of an agonist down regulation and
follicular stimulation by recombinant FSH. Fertilization will be achieved by standard IVF or
intracytoplasmic sperm injection. Fertilized eggs will be cultured in 6% CO2, 5% O2, 89% N2
atmosphere in microdrops. In the treatment group EmbryoGen culture medium (EG, Origio,
Måløv, Denmark) will be adopted throughout the culture period. In the control group,
inseminated oocytes will be cultured in standard culture conditions, i.e. IMS1 medium (ISM1,
Origio, Måløv, Denmark), maintaining unchanged all other culture conditions.
Procedures of embryo transfer, will be carried out on day 2 using EmbryoGen or ISM1
respectively. The endometrial support will be the same in the two groups.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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