Implant Infection Clinical Trial
Official title:
Short vs. Long Antibiotic Treatment of Implant-free Osteoarticular Infections
The investigators tested the working hypothesis if 4 weeks of systemic antibiotic treatment
in implant-related orthopaedic infections is non-inferior to 6 weeks after complete removal
of the infected implant. Randomization 1:1.
The study is completed. It halted prematurely and will not resume; participants are no longer
being examined or receiving intervention.
Former description of the study (now completed)
Osteoarticular infections related to orthopaedic implants are associated with substantial
morbidity, prolongation of hospital stay, and additional costs. Due to the increasing number
of patients with orthopaedic implants in Switzerland, similar to the rest of Europe and
elsewhere, the number of infections is expected to increase. While the surgical treatment of
these infections has been well studied, the ideal duration of antibiotic therapy after
removal (explantation) of the infected implant remains unknown. For almost 40 years, the
recommended total duration of post-explantation antibiotic therapy has been 6 weeks. This
recommendation is based on expert's personal experience rather than on prospective randomized
studies. Shorter treatment would decrease antibiotic-related adverse events and costs
hospital stay for patients awaiting an eventual reinsertion of a new implant. If physicians
and surgeon prescribe antibiotics for 6 weeks, this duration should be at least supported by
evidence.
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