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Impaired Synaptic Plasticity clinical trials

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NCT ID: NCT03504501 Terminated - Impaired Cognition Clinical Trials

Synaptic Plasticity and Cognitive Function in RASopathies

SynCoRAS
Start date: March 22, 2019
Phase: Phase 2
Study type: Interventional

The project is targeting cognitive impairment, one of the main health problems of patients with RAS pathway disorders. The aim of this study is to translate findings of animal studies to humans. This has been done by the applicants successfully for Lovastatin in Nf1. This result will be transferred to patients with Noonan Syndrome. lamotrigine is most likely a more effective and promising substance improving synaptic plasticity and consecutive cognitive function. It is expected that both substances are improving synaptic plasticity as well as alertness and changes in alertness may be a precondition for improvement of cognition.