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Synaptic Plasticity and Cognitive Function in RASopathies — SynCoRAS  

Impaired Cognition Clinical Trial

Official title:
Improvement of Synaptic Plasticity and Cognitive Function in RAS Pathway Disorders

Clinical Trial Summary

The project is targeting cognitive impairment, one of the main health problems of patients with RAS pathway disorders. The aim of this study is to translate findings of animal studies to humans. This has been done by the applicants successfully for Lovastatin in Nf1. This result will be transferred to patients with Noonan Syndrome. lamotrigine is most likely a more effective and promising substance improving synaptic plasticity and consecutive cognitive function. It is expected that both substances are improving synaptic plasticity as well as alertness and changes in alertness may be a precondition for improvement of cognition.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03504501
Study type Interventional
Source Technical University of Munich
Contact
Status Terminated
Phase Phase 2
Start date March 22, 2019
Completion date October 31, 2023
View Details
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