| Eligibility |
Inclusion Criteria:
- Aged 18-75, male or female;
- Rectal adenocarcinoma confirmed by histopathology;
- The lower margin of the tumor as assessed by MRI was below peritoneal reflex-and cT3
was associated with one or more risk factors(cT3c-d,cN1-2;MRF+;EMVI+);
- Patients who are expected to achieve R0 resection;
- Can swallow pills normally;
- ECOG PS 0-1;
- Have not received any previous anti-tumor therapy for rectal cancer, including
surgery, radiotherapy, chemotherapy, targeted therapy, immunotherapy, etc.;
- Surgical treatment is planned after completion of neoadjuvant therapy;
- No contraindications;
- Fertile female subjects shall have a negative serological pregnancy test within 72
hours prior to the start of trial drug administration and use effective contraceptive
methods during the trial and for at least 3 months after the last dose;For male
subjects with fertile female partners, effective contraceptive measures should be used
during the trial period and for 3 months after the last dose;
Exclusion Criteria:
- Have a history of allergy to monoclonal antibody, tirelizumab, capecitabine,
oxaliplatin or other platinum drugs;
- Have previously received or are currently receiving any of the following treatments:
A) any surgery, radiotherapy, chemotherapy, targeted therapy, immunotherapy for the tumor;
B) being treated with an immunosuppressive drug or systemic hormone for immunosuppression
purposes within 2 weeks prior to initial use of the study drug (dose >10mg/ day of
prednisone or equivalent);In the absence of active autoimmune disease, inhaled or topical
steroids and adrenocorticosteroid replacement at doses >10mg/ d of prednisone or equivalent
are permitted; C) received live attenuated vaccine within 4 weeks prior to initial use of
the study drug; D) major surgery or severe trauma within 4 weeks prior to first use of the
study drug;
- Have any active autoimmune disease or history of autoimmune disease, including but not
limited to: interstitial pneumonia, enteritis, hepatitis, hypophysitis, vasculitis,
nephritis, hyperthyroidism, hypothyroidism (may be considered after hormone
replacement therapy);Patients with complete remission of psoriasis or childhood
asthma/allergy who do not require any intervention as adults may be considered for
inclusion, but patients requiring medical intervention with bronchodilators may not be
included;
- A history of immunodeficiency, including HIV positive, or other acquired or congenital
immunodeficiency disease, or a history of organ transplantation or allogeneic bone
marrow transplantation;
- There is not a good control of the heart of the clinical symptoms or disease,
including but not limited to: such as (1) the NYHA class II or above for heart
failure, (2) the unstable angina, myocardial infarction occurred within 1 year (3),
(4) have clinical significance on the chamber of sex or ventricular arrhythmias
without clinical intervention or poorly controlled clinical intervention;
- Severe infection (CTCAE > level 2) occurred within 4 weeks prior to the first use of
the study drug, such as severe pneumonia, bacteremia, and complications of infection
requiring hospitalization;Baseline chest imaging suggests active lung inflammation,
signs and symptoms of infection within 14 days prior to initial use of the study drug,
or requiring oral or intravenous antibiotic treatment, except for prophylactic use of
antibiotics;
- Those who were found to have active pulmonary tuberculosis infection through medical
history or CT examination, or had active pulmonary tuberculosis infection history
within 1 year before enrollment, or had active pulmonary tuberculosis infection
history more than 1 year ago but without formal treatment;
- Presence of active hepatitis B (HBV DNA = 2000 IU/mL or 104 copies/mL), hepatitis C
(hepatitis C antibody positive and HCV RNA higher than the detection limit of analysis
method);
- Other malignancies diagnosed within 5 years prior to the first use of the study drug,
unless malignancies with a low risk of metastasis or death (5-year survival >90%),
such as adequately treated basal cell carcinoma of the skin or squamous cell carcinoma
of the skin or carcinoma in situ of the cervix, may be considered for inclusion;
- Pregnant or lactating women;
- In the investigator's judgment, there are other factors that may lead to forced
termination of the study, such as other serious medical conditions (including mental
illness) requiring concurrent treatment, alcoholism, drug abuse, family or social
factors, and factors that may affect the safety or compliance of the subjects.
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