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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01668615
Other study ID # jsxys-123
Secondary ID
Status Completed
Phase N/A
First received July 30, 2012
Last updated October 21, 2012
Start date January 2011
Est. completion date August 2012

Study information

Verified date October 2012
Source First Affiliated Hospital of Suzhou Medical College
Contact n/a
Is FDA regulated No
Health authority China: National Natural Science Foundation
Study type Observational

Clinical Trial Summary

The purpose of this study is to determine whether All-trans retinoic acid (ATRA) are effective in the treatment of refractory idiopathic thrombocytopenic purpura (RITP).


Description:

Idiopathic thrombocytopenic purpura(ITP), an acquired immune disease is characterized by impaired generation of autoantibody-specific platelet. At least 30% adult patients turn into refractory ITP. The pathogenesis of ITP remains to be elucidated. Now ,CD4+ helper cells have been classified as belong to T-helper 1(TH1), T-helper 2(TH2), T-helper17and Regulory T cell(Tregs). All-trans retinoic acid(ATRA) mainly applied in skin disease and acute promyelocytic leukemia. Recently, ATRA is also a immunomodulator which can induce differentiation, proliferation, apoptosis of cells, and immunomudulatory. In the international, the investigators first treat RITP with ATRA. To investigate the therapeutic effects of ATRA on RITP, and using new index in the cells, cytokines and molecular biology of three in-depth study of its mechanism.


Recruitment information / eligibility

Status Completed
Enrollment 35
Est. completion date August 2012
Est. primary completion date August 2012
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group N/A and older
Eligibility Inclusion Criteria:

- Clinical diagnosis of refratory idiopathic thrombocytopenic purpura

- Hormone and immune suppression, splenectomy is invalid

Exclusion Criteria:

- Other autoimmune diseases

Study Design

Observational Model: Case-Only, Time Perspective: Prospective


Related Conditions & MeSH terms


Intervention

Drug:
all-trans-retinoid acid
10 mg three times a day oral administration for 4 months

Locations

Country Name City State
China Jiangsu Institute of Hematology Suzhou Jiangsu

Sponsors (1)

Lead Sponsor Collaborator
First Affiliated Hospital of Suzhou Medical College

Country where clinical trial is conducted

China, 

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