Dietary Cholesterol & Defects in Cholesterol Synthesis in Mevalonate

Status Terminated

Clinical Trial Summary

Participants wanted for study of mevalonate kinase deficiency (MKD), mevalonic aciduria, or hyperimmunoglobulinemia with periodic fever syndrome (HIDS).

Patients with MKD (mevalonic aciduria or hyperimmunoglobulinemia with periodic fever syndrome (HIDS)) may be eligible for a research study conducted at Oregon Health & Science University (OHSU) in Portland, Oregon USA. The purpose of the study is to find out more about how these diseases affect body chemistry and health. The researchers also want to find out how cholesterol in the diet affect blood cholesterol and how the body handles cholesterol. This is a short-term and long-term dietary study. The long-term goal of this research is to see if controlling dietary cholesterol can decrease any of the symptoms of the diseases.

The study could involve up to 12 one-week admissions to OHSU over the course of 5 years.

Clinical Trial Description

Participants are admitted to the clinical research center for up to a week per visit. Additional visits at least yearly encouraged. During the week we measure such things as cholesterol absorption, sterol and bile acid synthesis, mevalonate and mevalonate shunt products, isoprenoids, fatty acids, leukotrienes, plasma cholesterol and other sterol levels. Also, the effects of altering dietary cholesterol on plasma 24-S OH-cholesterol, a measure of brain cholesterol turnover, will be evaluated. Studies of body composition/ metabolism/ growth, development, behavior, sleep, feeding, hearing and vision will be carried out to document the phenotype and determine if dietary intervention may be helpful.

The objective of the study is to characterize the metabolic and phenotypic consequences of MKD and study the effects of altering dietary cholesterol in MKD. We hypothesize that some of the phenotypic effects of MKD are due to altered cholesterol metabolism, but that the phenotype is predominantly due to derangements in isoprenoid metabolism. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00260299
Study type	Observational
Source	Oregon Health and Science University
Contact
Status	Terminated
Phase
Start date	February 2005
Completion date	January 31, 2016

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03663933` - Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation	Phase 2
Completed	`NCT03563066` - Effect of Benralizumab in Atopic Dermatitis	Phase 2
Recruiting	`NCT04339777` - Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity	Phase 2
Not yet recruiting	`NCT05969821` - Clonal Hematopoiesis of Immunological Significance
Completed	`NCT02916888` - A Study Comparing the Quality of Life of Patients in the Treatment of Eczema by Pediatric Generalists and Specialists	N/A
Completed	`NCT02527187` - Determination of the Sensitivity and Specificity of Prick Test Betula Verrucosa	Phase 2
Completed	`NCT01441076` - Anakinra for Behcet s Disease	Phase 1/Phase 2
Completed	`NCT01472263` - Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases	Phase 3
Completed	`NCT03720470` - Study Evaluating Efficacy and Safety of PF-04965842 and Dupilumab in Adult Subjects With Moderate to Severe Atopic Dermatitis on Background Topical Therapy	Phase 3
Suspended	`NCT04642066` - Cold Water Immersion and Atherosclerosis, Inflammation, Fat Accumulation and Lipid Profile Parameters	N/A
Completed	`NCT02294552` - Post-transplantation Cyclophosphamide as GVHD Prophylaxis After HSCT	Phase 2
Completed	`NCT01727973` - Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy	Phase 1/Phase 2
Completed	`NCT04103099` - Impact of HLNatural Immune Supplement on Colds	N/A
Recruiting	`NCT03344094` - Mechanism of Action of Ocrelizumab in Multiple Sclerosis	N/A
Active, not recruiting	`NCT05445284` - Group Education Trial to Improve Transition for Parents of Adolescents With T1D	N/A
Recruiting	`NCT06104111` - Epigenetic Memory of Vitamin D Supplementation	Phase 1
Not yet recruiting	`NCT05616117` - Next-generation Effects of Vitamin D Supplementation in Pregnancy
Completed	`NCT01510626` - Omalizumab With Oral Food Immunotherapy With Food Allergies Open Label Safety Study in a Single Center	Phase 1
Completed	`NCT01490177` - Single Center Food Allergy Oral Immunotherapy Study	Phase 1
Completed	`NCT03922087` - No-worry Baby Project

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Dietary Cholesterol and Defects in Cholesterol Synthesis in Mevalonate Kinase Deficiency

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms