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Clinical Trial Summary

The goal of the study is to learn about Safety and efficacy of preoperative adjuvant SOX regimen combined with PD-1 antibody versus FLOT Regimen with PD-1 antibody in localized deficient mismatch repair gastric cancer. The main question it aims to answer are: - Safety and efficacy of preoperative adjuvant SOX regimen combined with PD-1 antibody versus FLOT regimen with PD-1 antibody for the treatment of localized deficient mismatch repair gastric cancer - Disease-free survival of preoperative adjuvant SOX plus PD-1 antibody and FLOT plus PD-1 antibody for dMMR and locally advanced gastric cancer. Participants will be divided into two groups to use a FLOT chemotherapy regimen plus PD-1 antibody and a SOX chemotherapy regimen plus PD-1 antibody. Researchers would compare tumor regression grade, adverse effects and survival benefit of two preoperative adjuvant regimens.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06440811
Study type Interventional
Source Xijing Hospital
Contact Jipeng Li, Doctor
Phone 13991316190
Email jipeng1974@aliyun.com
Status Recruiting
Phase Phase 1
Start date January 1, 2024
Completion date March 1, 2025

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