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Ileus clinical trials

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NCT ID: NCT04433390 Completed - Clinical trials for Postoperative Ileus (Post Cardiac Surgery Constipation)

Effect of Naloxegol on Postoperative Ileus in Patients Undergoing Cardiac Surgery

TRANSIT
Start date: October 14, 2020
Phase: Phase 3
Study type: Interventional

Postoperative ileus, defined as the transient postoperative functional inhibition of propulsive bowel activity, commonly occurs in patients after cardiac surgery and contributes to postoperative morbidity. Naloxegol is a peripheral opioid receptor antagonist. Recent studies showed that naloxegol is effective in the treatment of chronic opioid-induced constipation but there is no data on its use in the management of postoperative ileus after cardiac surgery. The main objective of this prospective, double-blind, randomized, placebo-controlled trial is to assess the effectiveness of the perioperative use of naloxegol in reducing the duration of the postoperative ileus in patients undergoing cardiac surgery.

NCT ID: NCT04100447 Completed - Ileus Clinical Trials

A Study to Evaluate the Safety, Tolerability and Efficacy of LB1148 for Subjects Undergoing Elective Bowel Resection

Start date: November 5, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety, tolerability, and preliminary efficacy of LB1148 in subjects undergoing elective bowel resection. During abdominal surgery, surgeons handle, manipulate, and often make incisions in the bowel. These actions can create bruising, lesions, and microscopic damage to the bowel, which may allow digestive enzymes to cross the intestinal mucosal barrier potentially resulting in injury both locally and remotely. Leaking digestive enzymes may delay return of normal gastrointestinal (GI) function, lead to a lack of motility in the intestine (ileus), and promote the formation of intestinal scar tissue (adhesions).

NCT ID: NCT04057599 Completed - Clinical trials for Lumbar Spine Surgery Postoperative Ileus

Ileus After Lumbar Spine Surgery

Start date: August 17, 2019
Phase:
Study type: Observational

Postoperative ileus (POI) after lumbar spine surgery is not uncommon. However, the incidence, severity and risk factors of ileus after spine surgery remain uncertain because there is not yet a prospective investigation using a subjective grading evaluation tool.

NCT ID: NCT03887845 Completed - Postoperative Ileus Clinical Trials

Effects of Open and Laparoscopic Gastrointestinal Surgery on Gastrointestinal Function

Start date: August 1, 2018
Phase:
Study type: Observational [Patient Registry]

A prospective study to compare the postoperative ileus in open and laparoscopic gastrointestinal surgery through the determination of the time the patient takes to pass flatus, pass stool, bowel movement, oral intake, the time of hospital stay and total hospital costs. Postoperative ileus (POI) is one of the major focus of concern for surgeons, hospital executives, quality assurance directors as well as patients because of its role in causing patient distress, discomfort, and morbidity, leading to an increase in the duration of hospital stay and cost of care.

NCT ID: NCT03884244 Completed - Postoperative Ileus Clinical Trials

Postoperative Chewing Gum and Gynecological Laparoscopic Surgery

Start date: March 1, 2018
Phase: N/A
Study type: Interventional

The authors aimed to evaluate the effects of postoperative gum chewing on laparoscopic gynecological surgery, gastrointestinal function-intestinal mobility and early postoperative recovery. Patients undergoing elective gynecological laparoscopy were randomized. Demographic and characteristic features of the patients were recorded. Operation type, operation and anesthesia information were recorded. Patients underwent a postoperative routine regimen. Starting from the sixth hour, the sugar-free gum was crushed every 15 minutes until the gas was released. Postoperative follow-up was performed routinely. The first bowel movements, first bowel movements and first gas extraction and first decongestation periods were recorded.

NCT ID: NCT03852524 Completed - Postoperative Ileus Clinical Trials

Subcutaneous Methylnaltrexone Versus Placebo for Postoperative Ileus Prevention

Start date: February 21, 2019
Phase: Phase 2
Study type: Interventional

This randomized controlled trial will prospectively evaluate the clinical benefit for subcutaneous methylnaltrexone (MNTX) in counteracting the obstipatory (causing constipation) effects of spinal surgery without increasing narcotic usage or otherwise disrupting the recovery course of patients. Using a double-blind randomized design, either subcutaneous MNTX (0.15 mg/kg rounded to 8 mg or 12 mg) or placebo will be administered starting before surgery and then daily for three days. Information will be collected from medical records in IHIS up to 30 days prior to surgery and then for up to 30 days after surgery.

NCT ID: NCT03815877 Completed - Clinical trials for Cesarean Section Complications

The Effect of Caffeine Ingestion in Prevention of Postoperative Ileus After Caesarean Section.

Start date: January 17, 2018
Phase: N/A
Study type: Interventional

Many trials have been made to prevent paralytic ileus , including administration of prokinetic drugs , early resumption of feeding, gum chewing and adequate pain control. Unfortunately, none of these strategies has been completely successful. Recently the effect of caffeine on prevention of postoperative ileus after caesarian section was researched. That's why this study is designed to determine the efficacy of caffeine in prevention of postoperative ileus after caesarean section.

NCT ID: NCT03757442 Completed - Anastomotic Leak Clinical Trials

Peripheral Perfusion Index in Acute Surgical Patients

Start date: February 1, 2019
Phase:
Study type: Observational

Introduction Perioperative haemodynamic instability is associated with postoperative morbidity and mortality. Macrocirculatory parameters, such as the conventionally obtained mean arterial blood pressure and cardiac output, may be uncoupled from the microcirculation during sepsis and severe blood loss and may not necessarily be optimal resuscitation parameters. The peripheral perfusion index (PPI) is derived from the pulse oximetry signal and reflects perfusion. Reduced peripheral perfusion is associated with morbidity in critically ill patients and in patients following acute surgery. We hypothesize that patients with low intraoperative PPI demonstrate high frequency of postoperative complications and mortality regardless of blood pressure. Methods and analysis We plan to conduct a prospective observational cohort study in patients undergoing acute non-cardiac surgery (November 1st, 2017 to October 31st, 2018) at two University Hospitals. Data will be collected prospectively from patient records including patient demographics, comorbidity and intraoperative hemodynamic values, with PPI as the primary exposure variable, and postoperative complications and mortality within 30 and 90 days as outcome variables. We primarily assess association between PPI and outcome in multivariate regression models. Secondly, the predictive value of PPI for outcome, using area under the receiver operating characteristics curve is assessed. Ethics and dissemination Data will be reported according to The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE). Results will be published in a peer reviewed journal. The study is approved by the regional research ethics committee, storage and management of data has been approved by the Regional Data Protection Agency, and access to medical records is approved by the hospital board of directors at the involved hospitals and departments.

NCT ID: NCT03711487 Completed - Colorectal Surgery Clinical Trials

The Effect of Foeniculum Vulgare Ironing on Gastrointestinal Recovery After Colorectal Resection

Start date: October 20, 2018
Phase: Phase 2
Study type: Interventional

Chinese Medicine Ironing using Foeniculum vulgare has been applied in some departments to promote bowel function recovery, but the efficacy of ironing therapy remains uncertain after colorectal resection surgery.

NCT ID: NCT03386136 Completed - Ileus Clinical Trials

Therapeutic Oxygen for Gastrointestinal Atony (TOGA)

TOGA
Start date: January 25, 2018
Phase: Phase 1
Study type: Interventional

This study is a non invasive study to see if 100% oxygen therapy will help to resolve an intestinal obstruction.