The Protective Role of GABA Stimulation Before Ileostomy Closure

Status Not yet recruiting

Clinical Trial Summary

The goal of this clinical trial is to explore whether preoperative stimulation of the distal limb of the ileostomy loop with gamma aminobutyric acid (GABA) could effectively reduce the incidence of complications after ileostomy closure. Participants will be divided into two groups. One group included patients treated with stimulation of the efferent loop with GABA prior to transit reconstruction surgery; the other control group was stimulated without giving any substance. Researchers will compare incidence of complications such as postoperative ileus, diarrhea and other parameters such as time to tolerating a diet, start of the passage of flatus, start of the passage of stool, postoperative stay, etc.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Ileostomy; Complications

Clinical Trial Details

NCT number	NCT05905393
Study type	Interventional
Source	Qilu Hospital of Shandong University
Contact	Wei Guo, Dr.
Phone	0086-18560089725
Email	wguo@sdu.edu.cn
Status	Not yet recruiting
Phase	Phase 3
Start date	June 2023
Completion date	December 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05243771` - Norwegian Stoma Trial
Recruiting	`NCT04675606` - Implementing a Low Fiber Diet vs. Regular Diet in Postoperative Colorectal Patients With Ileostomies	N/A
Recruiting	`NCT03424447` - Stimulation of the Efferent Loop Before Loop Ileostomy Closure	Phase 2
Recruiting	`NCT05985499` - A Randomized Parallel-controlled Study Comparing the Ileostomy "Dumpling Suture Method" With Traditional Suture Method in Rectal Anterior Resection Surgery With Specimen Extraction Via Stoma	N/A
Terminated	`NCT03424954` - The Effect of a 30-day Automated Text Messaging Intervention on Hospital Based Acute Care Encounters Following Ileostomy	N/A
Recruiting	`NCT03982875` - Efficacy and Application of the Alfred SmartBag System After Ileostomy Creation in Colorectal Surgery: A Pilot Study	N/A
Completed	`NCT01881594` - Stimulation of Efferent Loop Prior to Ileostomy Closure	Phase 3
Completed	`NCT04169425` - Laparoscopic Surgery of Rectal Cancer and Ileostomy
Withdrawn	`NCT04669964` - Evaluating Ileostomy Hydration Protocol
Recruiting	`NCT05284864` - Timing Evaluation of Stoma Closure (TIMES). Early vs Late Closure of Stoma After Rectal Cancer Surgery.	N/A
Recruiting	`NCT05048329` - The Cascade Feasibility Pilot (Ileostomy)	N/A
Completed	`NCT06010043` - "Dumpling Suture Method" Versus Traditional Suture Method of Protective Loop Ileostomy in Laparoscopic Anterior Rectal Resection With Specimen Extraction Via Stoma: a Retrospective Comparative Study	N/A